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Digestive Diseases and Sciences

, Volume 53, Issue 2, pp 522–528 | Cite as

HLA DRB1*13 as a Risk Factor for Type 1 Autoimmune Hepatitis in North American Patients

  • Albert J. Czaja
  • Herschel A. Carpenter
  • S. Breanndan Moore
Original Paper

Abstract

Our goal was to determine if HLA DRB1*13 is associated with autoimmune hepatitis in North American patients. Two hundred and ten adults with definite type 1 autoimmune hepatitis were typed by DNA-based techniques, and the frequency of HLA DRB1*13 in patients without DRB1*03 and DRB1*04 was compared to that in 396 patients with eight other chronic liver diseases and 102 normal individuals. HLA DRB1*13 occurred more commonly in the autoimmune patients who lacked DRB1*03 and DRB1*04 than normal subjects who were similarly restricted (56% vs. 27%, P = 0.007). The frequency of HLA DRB1*13 was higher in autoimmune patients without DRB1*03 and DRB1*04 than in patients with other chronic liver diseases who were similarly restricted (59% vs. 32%, P = 0.01). Only patients with primary sclerosing cholangitis had a comparable occurrence of HLA DRB1*13. In conclusion, HLA DRB1*13 may be a genetic risk factor for some white North American patients with type 1 autoimmune hepatitis.

Keywords

Genetic predisposition Susceptibility factor Distinctions 

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Albert J. Czaja
    • 1
  • Herschel A. Carpenter
    • 2
  • S. Breanndan Moore
    • 2
  1. 1.Division of Gastroenterology and HepatologyMayo Clinic College of MedicineRochesterUSA
  2. 2.Department of Laboratory Medicine and PathologyMayo Clinic College of MedicineRochesterUSA

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