Digestive Diseases and Sciences

, Volume 52, Issue 12, pp 3358–3362 | Cite as

Hepatoid Adenocarcinoma of the Gallbladder

  • H. Gakiopoulou
  • N. Givalos
  • G. Liapis
  • G. Agrogiannis
  • E. Patsouris
  • I. Delladetsima


Hepatoid adenocarcinoma (HAC) is a rare variant of adenocarcinoma associated with hepatic differentiation in both morphological and functional terms [1]. HAC is defined as a tumor with aberrant hepatocellular differentiation occurring in extrahepatic organs, most commonly in the stomach [1]. This rare entity was first described by Ishikura et al. in 1985 as a specific type of primary gastric cancer [2]. Since then, HAC has been reported in various anatomic locations such as the esophagus, pancreas, ileum, papilla of Vater, uterus, ovary, lung, thymus, kidney, and urinary bladder [1]. Recognition of this rare entity is important for differential diagnostic and prognostic reasons as well. We present a rare case of HAC of the gallbladder which, to the best of our knowledge, constitutes the seventh reported case in the English literature.

Case report

Clinical summary

A 76-year-old woman presented with abdominal pain and complaints of general fatigue and loss of appetite....


Gallbladder Hepatoid adenocarcinoma 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • H. Gakiopoulou
    • 1
    • 4
  • N. Givalos
    • 2
  • G. Liapis
    • 3
  • G. Agrogiannis
    • 1
  • E. Patsouris
    • 1
  • I. Delladetsima
    • 3
  1. 1.A’ Department of PathologyMedical School, The National & Kapodistrian University of AthensAthensGreece
  2. 2.Department of SurgeryMedical School, The National & Kapodistrian University of AthensAthensGreece
  3. 3.Department of PathologyLaikon HospitalAthensGreece
  4. 4.AthensGreece

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