Hepatoid Adenocarcinoma of the Gallbladder
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Hepatoid adenocarcinoma (HAC) is a rare variant of adenocarcinoma associated with hepatic differentiation in both morphological and functional terms . HAC is defined as a tumor with aberrant hepatocellular differentiation occurring in extrahepatic organs, most commonly in the stomach . This rare entity was first described by Ishikura et al. in 1985 as a specific type of primary gastric cancer . Since then, HAC has been reported in various anatomic locations such as the esophagus, pancreas, ileum, papilla of Vater, uterus, ovary, lung, thymus, kidney, and urinary bladder . Recognition of this rare entity is important for differential diagnostic and prognostic reasons as well. We present a rare case of HAC of the gallbladder which, to the best of our knowledge, constitutes the seventh reported case in the English literature.
A 76-year-old woman presented with abdominal pain and complaints of general fatigue and loss of appetite....
KeywordsGallbladder Hepatoid adenocarcinoma
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