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Digestive Diseases and Sciences

, Volume 52, Issue 6, pp 1540–1547 | Cite as

Antiviral Response of HCV Genotype 1 to Consensus Interferon and Ribavirin Versus Pegylated Interferon and Ribavirin

  • Maria H. Sjogren
  • Robert SjogrenJr.
  • Michael F. Lyons
  • Michael Ryan
  • John Santoro
  • Coleman Smith
  • K. Rajender Reddy
  • Herbert Bonkovsky
  • Brooke Huntley
  • Sima Faris-Young
Original Article

Abstract

Achieving an antiviral response at a reasonable cost is a challenge in the treatment of patients with chronic hepatitis C. A previous study indicated that consensus interferon with ribavirin had promising activity against hepatitis C virus (HCV) genotype 1. The objective of this study was to determine the virologic response with consensus interferon or pegylated interferon α-2b plus weight-ribavirin in patients chronically infected with HCV genotype 1. Intention-to-treat analysis showed response in 37% and 41% of subjects treated with consensus interferon/ribavirin or pegylated interferon/ribavirin, respectively, with response rates of 42% and 44% observed in analysis of the per-protocol population, not a significant difference. Tolerability of the two treatment regimens was similar. In conclusion, both treatment regimens were safe and gave a similar antiviral response. It is possible that if consensus interferon is administered daily rather than three times weekly, eradication of HCV could be achieved in a larger proportion of patients infected with HCV genotype 1.

Keywords

Viral hepatitis Viral load Depression Quality of life African-American Interferon alfacon-1 

Notes

Acknowledgment

This work was supported in part by a grant from InterMune.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Maria H. Sjogren
    • 1
  • Robert SjogrenJr.
    • 2
  • Michael F. Lyons
    • 3
  • Michael Ryan
    • 4
  • John Santoro
    • 5
  • Coleman Smith
    • 6
  • K. Rajender Reddy
    • 7
  • Herbert Bonkovsky
    • 8
  • Brooke Huntley
    • 1
  • Sima Faris-Young
    • 9
  1. 1.Walter Reed Army Medical CenterWashingtonUSA
  2. 2.Kaiser PermanenteFalls ChurchUSA
  3. 3.Tacoma Digestive Diseases CenterTacomaUSA
  4. 4.Digestive and Liver Disease SpecialistsNorfolkUSA
  5. 5.Atlantic Gastroenterology Associates Egg Harbor Township New JerseyEgg Harbor TownshipUSA
  6. 6.Minnesota GastroenterologySt. PaulUSA
  7. 7.UPenn GI ResearchPhiladelphiaUSA
  8. 8.UConn Health CenterFarmingtonUSA
  9. 9.Intermune, Inc.BrisbaneUSA

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