Digestive Diseases and Sciences

, Volume 53, Issue 10, pp 2789–2792 | Cite as

Lactulose/Mannitol Test and Specificity, Sensitivity, and Area under Curve of Intestinal Permeability Parameters in Patients with Liver Cirrhosis and Crohn's Disease

  • Milan Dastych
  • Milan DastychJr
  • Hana Novotná
  • J. Číhalová
Original Paper


The purpose of this study was to investigate and compare the specificity, sensitivity, and area under curve (AUC) of the lactulose/mannitol ratio, lactulose/creatinine ratio, and lactulose recovery and their diagnostic value for intestinal permeability assessment within the absorption lactulose/mannitol (L/M) test. Results The value of the lactulose/mannitol ratio, lactulose/creatinine ratio, and the percentage of lactulose recovery in Crohn’s disease (0.0763 ± 0.0369; 99.62 ± 67.87; 1.0478 ± 0.6148) and in liver cirrhosis (0.0517 ± 0.0365; 54.65 ± 53.26; 0.838 ± 0.929) were significantly different from the values measured in the control group (0.0123 ± 0.0081; 10.95 ± 7.07; 0.2438 ± 0.1568), P < 0.0001–0.002). In Crohn’s disease, specificity, sensitivity, and AUC were 100%, 89.5%, and 0.987, respectively, of the lactulose/mannitol ratio at a cut-off level of 0.022. In liver cirrhosis, the test characteristics were 88.5%, 84.2%, and 0.910 at a cut-off level of 0.018. Conclusion The lactulose/mannitol ratio was evaluated to have the highest diagnostic value to assess intestinal permeability.


Lactulose Mannitol Intestinal permeability Sensitivity Specificity Area under curve 



This work was supported by the Grant Agency of the Health Ministerium, Czech Republic NR9084-3.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Milan Dastych
    • 1
    • 2
  • Milan DastychJr
    • 3
  • Hana Novotná
    • 1
    • 2
  • J. Číhalová
    • 1
    • 2
  1. 1.Department of Clinical Biochemistry and HematologyUniversity Hospital BrnoBrnoCzech Republic
  2. 2.Department of Laboratory Methods, Faculty of MedicineMasaryk UniversityBrnoCzech Republic
  3. 3.Department of Internal Medicine and GastroenterologyUniversity Hospital BrnoBrnoCzech Republic

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