Is Oral l-Acyl-Carnitine an Effective Therapy for Hepatic Encephalopathy? Review of the Literature
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Hepatic encephalopathy (HE) is a significant cause of morbidity and mortality in patients with advanced chronic liver disease. Current therapies are associated with inconvenient side-effects, high cost, and incomplete efficacy. The quanternary ammonium compound l-acyl-carnitine has been suggested as a potent, low-cost, and safe alternative therapy for patients with cirrhosis and HE. A systematic review of the literature assessing the use of carnitine in the treatment of HE identified three high-quality human trials for review. Analysis of the selected carnitine trials compared to currently accepted therapies suggests that l-acyl-carnitine is promising as a safe and effective treatment for HE, and further trials of this drug are warranted.
KeywordsCarnitine Hepatic encephalopathy Cirrhosis Portal hypertension
Thanks are due to Drs. John Baillie, MB, ChB, FRCP and Girish Mishra, MD, MS for their assistance in reviewing this article before submission.
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