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Digestive Diseases and Sciences

, Volume 52, Issue 9, pp 2166–2169 | Cite as

Can Soluble Triggering Receptor Expressed on Myeloid Cells (sTREM-1) Be Considered an Anti-Inflammatory Mediator in the Pathogenesis of Peptic Ulcer Disease?

  • Vassilios Koussoulas
  • Michalis Tzivras
  • Evangelos J. Giamarellos-Bourboulis
  • Maria Demonakou
  • Spyridon Vassilliou
  • Aimilia Pelekanou
  • Antonios Papadopoulos
  • Helen Giamarellou
  • Charalambos Barbatzas
ORIGINAL PAPER

Abstract

Soluble triggering receptor expressed on myeloid cells (sTREM-1) is a novel mediator involved in the pathogenesis of peptic ulcer disease. To investigate the potential role of sTREM-1 in the anti-inflammatory response in chronic gastritis, sTREM-1 was compared with other anti-inflammatory mediators of gastritis. Forty patients with dyspepsia were enrolled: 20 with peptic ulcer and 20 controls without any macroscopic abnormalities. All patients were examined by endoscopy; gastric juice was aspirated and biopsy specimens were collected from the antrum and corpus of the stomach. sTREM-1, interleukin (IL)-8, and IL-10 were estimated by enzyme immunoassays. Median sTREM-1 in patient controls and in patients with peptic ulcer disease was 3.91 and 44.27 pg/ml, respectively (P=0.006). Respective values of IL-8 were 1856.97 and 2030.66 pg/ml (P=0.023); those of IL-10 were 16.92 and 18.43 pg/ml (NS). The odds ratio for the presence of peptic ulcer in the event of a concentration of sTREM-1 higher than 15 pg/ml was 23.22 (95% CI, 2.58–208.62; P=0.002). A positive correlation was found between the ratios of IL-8/sTREM-1 and IL-8/IL-10 (r s, + 0.365; P=0.021). In conclusion, sTREM-1 is an independent factor for the generation of peptic ulcer disease and might behave as an anti-inflammatory mediator in chronic gastritis.

Keywords

STREM-1I Interleukin-10 Pathogenesis Chronic gastritis Peptic ulcer 

References

  1. 1.
    Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE (2004) Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med 350:451–458PubMedCrossRefGoogle Scholar
  2. 2.
    Gibot S, Kolopp-Sarda MN, Bene MC, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC (2004) A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med 200:1419–1426PubMedCrossRefGoogle Scholar
  3. 3.
    Knapp S, Gibot S, De Vos A, Versteeg HH, Colonna M, van der Poll T (2004) Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxinemia. J Immunol 173:7131–7134PubMedGoogle Scholar
  4. 4.
    Koussoulas V, Vassiliou S, Demonakou M, Giamarellos-Bourboulis EJ, Tassias G, Mouktaroudi M, Giamarellou H, Barbatzas C (2005) Soluble triggering receptor expressed on myeloid cells (sTREM-1): a new mediator involved in the pathogenesis of peptic ulcer disease. Eur J Gastroenterol Hepatol 18:375–379CrossRefGoogle Scholar
  5. 5.
    Giamarellos-Bourboulis EJ, Zakynthinos S, Baziaka F, Papadomichelakis E, Virtzili S, Koutoukas P, Armaganidis A, Giamarellou H, Roussos C (2006) Soluble triggering receptor on myeloid cells (sTREM-1) as an anti-inflammatory mediator in sepsis. Intensive Care Med 237–243Google Scholar
  6. 6.
    Bodger K, Wyatt JI, Heatley RV (1997) Gastric mucosa secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumour necrosis factor-alpha secretion. Gut 40:739–744PubMedCrossRefGoogle Scholar
  7. 7.
    Hellmig S, Hampe J, Folsch UR, Schreiber S (2004) Role of IL-10 promoter haplotypes in Helicobacter pylori associated gastric inflammation. Gut 53:1082–1089CrossRefGoogle Scholar
  8. 8.
    Kohler B, Maier M, Benz C, Riemann JF (1997) Acute ulcer bleeding. A prospective randomized trial to compare Doppler and Forrest classifications in endoscopic diagnosis and therapy. Dig Dis Sci 42:1370–1374PubMedCrossRefGoogle Scholar
  9. 9.
    Dixon MF, Genta RM, Yardley JH, Correa P (1996) Classification and grading of gastritis. The updated Sydney System. Am J Surg Pathol 20:1161–1181PubMedCrossRefGoogle Scholar
  10. 10.
    Zhang C, Yamada N, Wu YL, Wen M, Matsuhisa T, Matsukura N (2005) Comparison of Helicobacter pylori infection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients. World J Gastroenterol 11:976–981PubMedGoogle Scholar
  11. 11.
    Bodger K, Bromelow K, Wyatt JI, Heatley RV (2001) Interleukin-10 in Helicobacter pylori associated gastritis: immunohistochemical localization and in vitro effects on cytokine secretion. J Clin Pathol 54:285–292PubMedCrossRefGoogle Scholar
  12. 12.
    Kasama T, Miwa Y, Isozaki T, Odai T, Adachi M, Kunkel SL (2005) Neutrophil-derived cytokines: potential therapeutic targets in inflammation. Curr Drug Targets Inflamm Allergy 4:273–279PubMedCrossRefGoogle Scholar
  13. 13.
    Pease JE, Sabroe I (2002) The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy. Am J Respir Med 1:19–25PubMedGoogle Scholar
  14. 14.
    Eaton KA, Mefford M, Thevenot T (2001) The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 166:7456–7461PubMedGoogle Scholar
  15. 15.
    Figueiredo C, Machado JC, Yamaoka Y (2005) Pathogenesis of Helicobacter pylori infection. Helicobacter 10 (Suppl 1):14–20PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Vassilios Koussoulas
    • 1
    • 5
  • Michalis Tzivras
    • 2
  • Evangelos J. Giamarellos-Bourboulis
    • 3
  • Maria Demonakou
    • 4
  • Spyridon Vassilliou
    • 1
  • Aimilia Pelekanou
    • 3
  • Antonios Papadopoulos
    • 3
  • Helen Giamarellou
    • 3
  • Charalambos Barbatzas
    • 1
  1. 1.Department of GastroenterologySismanoglion General Hospital of AthensAthensGreece
  2. 2.Department of Pathophysiology, Gastroenterology SectionAthens Medical SchoolAthensGreece
  3. 3.Fourth Department of Internal MedicineAthens Medical SchoolAthensGreece
  4. 4.Department of PathologySismanoglion General Hospital of AthensAthensGreece
  5. 5.Sismanoglion General HospitalAthensGreece

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