Proton Pump Inhibitors Improve Acid-Related Dyspepsia in Gastroesophageal Reflux Disease Patients
- 270 Downloads
It has been reported that proton pump inhibitors are more effective than H2 receptor antagonists in patients with functional dyspepsia. Dyspeptic symptoms that respond to proton pump inhibitors are classified as acid-related dyspepsia. A new questionnaire for assessing gastroesophageal reflux disease (GERD), the Frequency Scale for Symptoms of GERD, covers the 12 most common symptoms of GERD patients. A quantitative assessment of the changes of reflux symptoms and acid-related dyspepsia was made in GERD patients receiving proton pump inhibitor therapy. Sixty-eight GERD patients receiving proton pump inhibitor therapy completed the questionnaire before and after treatment for 8 weeks. There is a significant positive correlation between reflux symptoms and acid-related dyspepsia before and after therapy (r = 0.569 and r = 0.569; both P’s < 0.001) and acid-related dyspepsia in patients with both nonerosive and erosive GERD. We conclude that GERD patients suffer not only from reflux symptoms, but also from acid-related dyspepsia, and proton pump inhibitors improve both types of symptoms.
KeywordsAcid-related dyspepsia Frequency scale for symptoms of GERD Gastroesophageal reflux disease Proton pump inhibitor
- 2.Dupuy HJ (1984) The psychological general well-being (PGWB) index. In: Wenger NK, Mattson ME, Furberg CD, et al. (eds) Assessment of quality of life in clinical trials of cardiovascular therapies. Le Jacq, New York, pp 170–183Google Scholar
- 8.Hoshihara Y (1998) Reflux esophagitis. In: Nagasako K, Fujimori T, Hoshihara Y, Tabuchi M (eds) Atlas of gastroenterologic endoscopy by high-resolution video-endoscope. Igaku-Shoin, Tokyo, p 32Google Scholar