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Digestive Diseases and Sciences

, Volume 52, Issue 10, pp 2695–2702 | Cite as

Pilot Studies to Demonstrate That Intestinal Mucosal Afferent Nerves Are Functionally Linked to Visceral Adipose Tissue

  • Felix W. Leung
  • Vay Liang W. Go
  • Oscar U. Scremin
  • Andre Obenaus
  • Michael L. Tuck
  • Michael S. Golub
  • Peter Eggena
  • Joseph W. Leung
Original Article

Abstract

Dietary capsaicin reduces rodent visceral fat weight. We tested the hypothesis that intact intestinal mucosal afferent nerve function is necessary for fat deposition in visceral adipose tissue sites. Rats were treated daily for 2 weeks with intragastric (chronic treatment) vehicle or capsaicin. Superior mesenteric artery blood flow and mesenteric and inguinal fat blood flow were measured before and after capsaicin was administered into the duodenum (acute treatment). Fat from all sites was dissected and weighed. Chronic capsaicin significantly attenuated acute capsaicin-induced mesenteric hyperemia but did not abolish the reflex wiping of the eye exposed to capsaicin, indicating that functional ablation was limited to the intestinal mucosal afferent nerves. The associated vasoconstriction in adipose tissue was inhibited at the visceral (mesenteric) site and maintained but attenuated at the subcutaneous (inguinal) site. The onset of vasoconstriction was instantaneous, indicating a reflex mechanism. There was a redistribution of fat from visceral to subcutaneous sites, reflected by a decrease and an increase in the percentage of body fat in the visceral and subcutaneous sites, respectively. These pilot studies reveal for the first time that normal intestinal mucosal afferent nerve function is necessary for the physiologic accumulation of fat in visceral adipose tissue sites.

Keywords

Capsaicin Capsaicin-sensitive afferent nerves Pulse Doppler flowmetry Hydrogen gas clearance Laser Doppler flowmetry Adipose tissue blood flow Mesenteric artery blood flow 

Notes

Acknowledgment

This work was supported in part by VA Medical Research Funds (F.W.L.), Mr. C. W. Law Research Funds (J.W.L.), and NCI 1 P01 CA42710, UCLA Clinical Nutrition Research Unit (V.L.W.G.)

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Felix W. Leung
    • 1
    • 3
    • 5
    • 8
  • Vay Liang W. Go
    • 4
    • 5
  • Oscar U. Scremin
    • 2
    • 3
    • 5
  • Andre Obenaus
    • 6
  • Michael L. Tuck
    • 1
    • 3
    • 5
  • Michael S. Golub
    • 1
    • 3
    • 5
  • Peter Eggena
    • 1
    • 3
    • 5
  • Joseph W. Leung
    • 7
  1. 1.Research and Medical ServicesSepulveda Ambulatory Care Center and Nursing HomeSepulvedaUSA
  2. 2.West Los Angeles Veterans Affairs Medical CenterWest Los AngelesUSA
  3. 3.Veterans Affairs Greater Los Angeles Healthcare SystemSepulvedaUSA
  4. 4.Department of Medicine, University of California, Los AngelesLos AngelesUSA
  5. 5.David Geffen School of Medicine at University of California, Los AngelesLos AngelesUSA
  6. 6.Department of Radiation MedicineLoma Linda University School of MedicineLoma LindaUSA
  7. 7.Sacramento Veterans Affairs Medical CenterNorthern California Healthcare System, and University of California, DavisSacramentoUSA
  8. 8.Division of Gastroenterology (111G)Sepulveda Ambulatory Care Center and Nursing Home, Veterans Affairs Greater Los Angeles Healthcare SystemSepulvedaUSA

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