Skip to main content
SpringerLink
Log in

Molecular Analysis of the p53 Gene in Patients with Intestinal Metaplasia of the Cardia and Barrett's Esophagus: Characterization by Sequencing

  • Letter to the Editor
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Segal F, Kaspary APB, Prolla JC, Leistner S (2004) p53 overexpression and p53 mutation analysis in patients with intestinal metaplasia of the cardia and Barretts esophagus. Cancer Lett 210:213–218

    Article  PubMed  CAS  Google Scholar 

  2. Miller SA, Dikes DD, Polensky HF (1998) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16(7):1215

    Google Scholar 

  3. Li LY, Tang JT, Jia LQ, Li PW (2005) Mutations of p53 gene exons 4-8 in human esophageal cancer. World J Gastroenterol 11(19):2998–3001

    PubMed  CAS  Google Scholar 

  4. Ireland AP, Clarck GWB, DeMeester TR (1997) The significance of p53 in clinical practice. Ann Surg 225(1):17–30

    Article  PubMed  CAS  Google Scholar 

  5. IARC Homepage (2005) International Agency for Research on Cancer—p53 polymorphisms. Available at: http://www.iarc. fr/p53/index.html; accessed December 23, 2005

  6. Garewal HS (2003) What is the comparative rate of p53 overexpression in Barretts patients with and without dysplasia? In: Giuli R, Siewert JR, Couturier D, Scarpignato C (eds) Barretts esophagus, 1st ed. John Libbey Eurotext, Paris, pp 390–391

    Google Scholar 

  7. Kubba AK, Poole NA, Watson A (1999) Role of p53 assessment in management of Barretts esophagus. Dig Dis Sci 44(4):659–667

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This work received editorial support from the Research and Postgraduate Group of Hospital de Clínicas in Porto Alegre (RS, Brazil) and financial support from the Research Support Foundation of Rio Grande do Sul (FAPERGS), Coordination for the Improvement of Higher Education Personnel (CAPES), and Research Support Fund/Hospital de Clínicas in Porto Alegre (FIPE-HCPA).

Author information

Authors and Affiliations

  1. Postgraduate Program in Medical Sciences, School of Medicine, Federal University of Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre, 90035-903,, Brasil

    Diogo André Pilger

  2. Medical Genetic Service, Hospital de Clínicas in Porto Alegre, Ramiro Barcelos 2350, Porto Alegre, 90035-903,, Brasil

    Patricia L. Lopez & Sandra Leistner-Segal

  3. Institute of the Digestive Tract (Instituto do Aparelho Digestivo-IAD), Brasilia, Brazil

    Fâbio Segal

Authors
  1. Diogo André Pilger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Patricia L. Lopez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fâbio Segal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sandra Leistner-Segal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Diogo André Pilger.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pilger, D.A., Lopez, P.L., Segal, F. et al. Molecular Analysis of the p53 Gene in Patients with Intestinal Metaplasia of the Cardia and Barrett's Esophagus: Characterization by Sequencing. Dig Dis Sci 52, 2183–2185 (2007). https://doi.org/10.1007/s10620-006-9526-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-006-9526-1

Keywords

Search

Navigation