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Digestive Diseases and Sciences

, Volume 52, Issue 2, pp 594–597 | Cite as

Methylphenidate-Induced Autoimmune Hepatitis

  • Jason J. Lewis
  • Julia C. Iezzoni
  • Carl L. Berg
Case Report

Introduction

Autoimmune hepatitis (AIH) is a chronic necroinflammatory disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level [1]. The pathogenesis is proposed to result from a genetically predisposed host being exposed to an environmental agent that triggers an autoimmune process directed at liver antigens causing continued inflammation that results in fibrosis and often cirrhosis [1]. The diagnosis is characterized by serologic markers such as antinuclear antibodies (ANAs), anti-smooth muscle antibody (anti-SMA), antiactin antibody, anti-liver/kidney microsomal antibody (anti-LKMA), and elevated serum globulins, most notably immunoglobulin G (IgG) [1]. Anti-inflammatory/immunosuppressive therapy is effective, with an initial remission rate of 80%, with prognosis inversely proportional to histologic severity of disease [1].

Many pharmacological agents have been suspected as triggering agents for AIH including methyldopa, nitrofurantoin,...

Keywords

Autoimmune hepatitis Methylphenidate Liver transplantation 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • Jason J. Lewis
    • 1
  • Julia C. Iezzoni
    • 2
  • Carl L. Berg
    • 3
  1. 1.Department of Internal MedicineUniversity of Virginia Health SystemCharlottesvilleUSA
  2. 2.Department of PathologyUniversity of Virginia Health SystemCharlottesvilleUSA
  3. 3.Division of Gastroenterology and HepatologyUniversity of Virginia Health SystemCharlottesvilleUSA

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