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Digestive Diseases and Sciences

, Volume 52, Issue 1, pp 287–291 | Cite as

Oral Carbohydrate Solution Ameliorates Endotoxemia-Induced Splanchnic Ischemia

  • Turgut Deniz
  • Canan Agalar
  • Mehmet Ozdogan
  • Faruk Comu
  • Mustafa Emirdogan
  • Seda Taskin
  • Oral Saygun
  • Fatih Agalar
Original Article

Abstract

The purpose of this study was to investigate the effect of oral administration of a simple carbohydrate solution on splanchnic circulation and bacterial translocation in endotoxemia. Group 1 was sham control; group 2 was starved for 24 hours; in group 3, endotoxin was administrated at the end of starvation; in group 4, carbohydrate solution was administrated via orogastric route for 24 hours; and in group 5, carbohydrate solution was given and endotoxin was administrated at the end of 24 hours. Splanchnic blood flows were recorded and tissue samples were collected for microbiological analyses. There was a significant increase (P<.05) in the incidence of bacterial translocation in starvation. Endotoxemia decreased distal (P=.021) and midmesenteric (P=.046) flow in starved animals. Oral carbohydrate significantly increased ileal blood flow in starvation (P=.036) and endotoxemia (P=.008). In conclusion, oral carbohydrate solution prevents bacterial translocation during starvation and endotoxemia. The possible mechanism is the improvement in the mesenteric blood flow.

Keywords

Oral carbohydrate solution Maltodextrin Bacterial translocation Splanchnic ischemia Mesenteric blood flow 

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Copyright information

© Springer Science&#x002B;Business Media, Inc. 2006

Authors and Affiliations

  • Turgut Deniz
    • 1
  • Canan Agalar
    • 2
  • Mehmet Ozdogan
    • 3
  • Faruk Comu
    • 4
  • Mustafa Emirdogan
    • 5
  • Seda Taskin
    • 2
  • Oral Saygun
    • 5
  • Fatih Agalar
    • 5
  1. 1.Department of Emergency MedicineKirikkale University School of MedicineKirikkaleTurkey
  2. 2.Department of Infectious Diseases and Clinical MicrobiologyKirikkale University School of MedicineKirikkaleTurkey
  3. 3.Department of General SurgeryAtaturk Egitim ve Arastirma Hospital, Mertler sok. 41/7 BestepeAnkaraTurkey
  4. 4.Department of PhysiologyKirikkale University School of MedicineKirikkaleTurkey
  5. 5.Department of General SurgeryKirikkale University School of MedicineKirikkaleTurkey

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