De Novo Hepatocellular Carcinoma Occurring in a Transplanted Liver: Case Report and Review of the Literature
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One of the main indications for liver transplantation in patients with end-stage liver disease is hepatitis C virus (HCV)-induced cirrhosis [1, 2]. Cirrhosis from any cause may give rise to hepatocellular carcinoma (HCC). Recurrence of HCV infection in the liver allograft is almost universal and may lead to graft failure and/or cirrhosis in between 10 and 30% of cases within 5 years [3, 4, 5]. Only two cases have been previously reported in the medical literature in which HCC developed in the liver allograft in the setting of recurrent HCV and cirrhosis [6, 7]. We report an additional case of de novo HCC in a cirrhotic allograft with recurrent hepatitis C.
KeywordsLiver transplantation Immunosuppression De novo hepatocellular carcinoma Hepatitis C
We thank Dr. Swan N. Thung for her input on the manuscript.