Digestive Diseases and Sciences

, Volume 51, Issue 10, pp 1780–1782 | Cite as

De Novo Hepatocellular Carcinoma Occurring in a Transplanted Liver: Case Report and Review of the Literature

  • Anca Croitoru
  • Thomas D. Schiano
  • Myron Schwartz
  • Sasan Roayaie
  • Ruliang Xu
  • Arief Suriawinata
  • M. Isabel Fiel
Case Report


One of the main indications for liver transplantation in patients with end-stage liver disease is hepatitis C virus (HCV)-induced cirrhosis [1, 2]. Cirrhosis from any cause may give rise to hepatocellular carcinoma (HCC). Recurrence of HCV infection in the liver allograft is almost universal and may lead to graft failure and/or cirrhosis in between 10 and 30% of cases within 5 years [3, 4, 5]. Only two cases have been previously reported in the medical literature in which HCC developed in the liver allograft in the setting of recurrent HCV and cirrhosis [6, 7]. We report an additional case of de novo HCC in a cirrhotic allograft with recurrent hepatitis C.

Case report

A 61-year-old Caucasian man underwent an orthotopic liver transplantation (OLT) on March 7, 1996, for end-stage liver disease due to HCV cirrhosis and concomitant nonalcoholic steatohepatitis. Imaging studies performed prior to OLT revealed a cirrhotic liver without focal lesions. The serum α-fetoprotein...


Liver transplantation Immunosuppression De novo hepatocellular carcinoma Hepatitis C 



We thank Dr. Swan N. Thung for her input on the manuscript.


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Anca Croitoru
    • 1
  • Thomas D. Schiano
    • 2
    • 3
  • Myron Schwartz
    • 2
  • Sasan Roayaie
    • 2
  • Ruliang Xu
    • 1
  • Arief Suriawinata
    • 1
  • M. Isabel Fiel
    • 1
  1. 1.The Lillian and Henry M. Stratton-Hans Popper Department of PathologyThe Mount Sinai Medical CenterNew YorkUSA
  2. 2.The Recanati-Miller Transplantation InstituteThe Mount Sinai Medical CenterNew YorkUSA
  3. 3.Adult Liver TransplantationMount Sinai Medical CenterNew YorkUSA

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