Digestive Diseases and Sciences

, Volume 51, Issue 10, pp 1777–1779 | Cite as

Remission of Digestive Insufficiency by Islet Transplantation to the Pancreas

Basic Research


Pancreatic digestive insufficiency is a common problem in both Type 1 and Type 2 diabetes and remains a serious consequence of diabetes in developing countries. The problem is not corrected by supportive therapies including exogenous insulin injections. It is our hypothesis that digestive insufficiency may be corrected or diminished by the transplantation of islets to the pancreas, thereby supplying islet hormones directly to acinar tissue analogous to the normal pancreas. Diabetic rats received 1000 syngeneic islets and dogs received 7600 autologous islets per kilogram as a transplant to the pancreas. Blood glucose and amylase concentrations were normalized in islet recipients in contrast with controls receiving no islets or islets transplanted to the renal capsule. These results suggest that diabetic digestive insufficiency may be corrected by intrapancreatic islet transplantation.


Islet transplantation Digestive insufficiency Diabetes 



This work was supported by the Department of Veterans Affairs.


  1. 1.
    Frier BM, Saunders JHD, Wormsley KG, Bouchier LAD (1976) Exocrine pancreatic function in juvenile-onset diabetes mellitus. Gut 17:685–691PubMedGoogle Scholar
  2. 2.
    Kawamori R, Katsura M, Isheida S, Yamasaki Y (1995) Substantial exocrine pancreatic derangement in human diabetic patients evaluated from pure pancreatic juice. J Diabet Complicat 9:69–73CrossRefGoogle Scholar
  3. 3.
    Loini R, Cortoni L, Scotta M, Melze d’Eril G, Seve F (1990) Exocrine pancreatic function in children with insulin dependent diabetes mellitus. Diabetes Res Clin Pract 8:261–267Google Scholar
  4. 4.
    Rothenbacker D, Low M, Hardt P, Klor H-U, Ziegler H, Brenner H (2005) Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study. Scand J Gastroenterol 40:697–704Google Scholar
  5. 5.
    Hardt PD, Krauss A, Bretz L, Porsch-Ozcurumez M, Schnell-Ketschmer H, Maser E, Bretzel RG, Zekhorn T, Klor H-U (2000) Pancreatic exocrine function in patients with Type 1 and Type 2 diabetes mellitus. Acta Diabetol 37:105–110PubMedCrossRefGoogle Scholar
  6. 6.
    Nakagawa A, Stagner JI, Samols E (1993) Suppressive role of the islet-acinar axis in the perfused rat pancreas. Gastroenterology 105:868–875PubMedGoogle Scholar
  7. 7.
    Nakagawa A, Samols E, Stagner JI (1993) Interstitial acinar islet hormone concentrations in the dog pancreas. Am J Physiol 264:G728–G734PubMedGoogle Scholar
  8. 8.
    Kvist-Reimer M, Mokshagundam SP, Wyler K, Sundler F, Ahren B, Stagner J (2003) Beneficial effect of local growth factor treatment on autonomic reinnervation of transplanted pancreatic islets in rats. Pancreas 29:392–397CrossRefGoogle Scholar
  9. 9.
    Stagner JI, Mokshagundam SP, Samols E (1998) Induction of mild hypoglycemia by islet transplantation to the pancreas. Transplant Proc 30:635–636PubMedCrossRefGoogle Scholar
  10. 10.
    Rodriguez-Rilo HL, Carroll PB, Zeng YJ, Fontes P, Demetris J, Ricordi C (1994) Acceleration of chronic failure of intrahepatic canine islet autografts by a short course of prednisone. Transplantation 57:181–187CrossRefGoogle Scholar
  11. 11.
    Samols E, Stagner JI (1996) Intra-islet cell-cell interactions and insulin secretion. Diabetes Rev 4:207–223Google Scholar
  12. 12.
    Williams JA, Goldfine ID (1985) The insulin-pancretic acinar axis. Diabetes 34:980–986PubMedGoogle Scholar
  13. 13.
    Holst JJ (1987) Does the endocrine secretion of the pancreas exert a local control of the exocrine secretion? Pancreas 2:613–619PubMedCrossRefGoogle Scholar
  14. 14.
    Garry DJ, Garry MG, Williams JA, Mahoneey WC, Sorenson RL (1989) Effects of islet hormones on amylase secretion and localization of somatostatin binding sites. Am J Physiol 56:G897–G904Google Scholar
  15. 15.
    Kimmel JD, Pollaock HG (1981) Target organs for avain pancreatic polypeptide. Endocrinology 109:1693–1699PubMedCrossRefGoogle Scholar
  16. 16.
    Louie DS, Williams JA, Owyang C (1985) Action of pancreatic polypeptide on rat pancreatic secretion in vivo and in vitro. Am J Physiol 249:G489–G495Google Scholar
  17. 17.
    Nakagawa A, Stagner JI, Samols E (1995) In situ binding of islet hormones in the isolated rat pancreas. Evidence for local high concentrations of islet hormones via the islet-acinar axis. Diabetologia 38:262–268PubMedGoogle Scholar
  18. 18.
    Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhi E, Kneteman NM, Lakey JRT, Shapiro AMJ (2005) Five-year follow-up after clinical islet transplantation. Diabetes 54:2060–2069PubMedGoogle Scholar
  19. 19.
    Warnock GL, Rajotte RV (1988) Critical mass of purified islets that induce normoglycemia after implantation into dogs. Diabetes 37:467–470PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006 2006

Authors and Affiliations

  • John I. Stagner
    • 1
  • Horacio L. Rilo
    • 2
  • Karen Wyler
    • 1
  1. 1.Department of Veteran Affairs Medical CenterEducation OfficeLouisvilleUSA
  2. 2.Department of SurgeryUniversity of Cincinnati School of MedicineCincinnatiUSA

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