Digestive Diseases and Sciences

, Volume 52, Issue 9, pp 2403–2409 | Cite as

Levels of Hepatitis B Virus (HBV) Replication During the Nonreplicative Phase: HBV Quantification by Real-Time PCR in Korea

  • Hyung Joon Yim
  • Kwan Soo Byun
  • Yun Jung Chang
  • Yeon Seok Suh
  • Jong Eun Yeon
  • Chang Hong Lee
  • Jung Ah Kwon
  • Wangdon Yoo
  • Soo-Ok Kim
  • Sun Pyo Hong
Original Paper


The levels of HBV replication in the nonreplicative phase are not clear. We conducted this study to evaluate the levels of viral replication during the nonreplicative phase in chronic HBV-infected Korean patients using real-time PCR. A total of 125 patients were classified into three groups: inactive HBsAg carriers, inactive liver cirrhosis patients, and resolved chronic HBV-infected patients with loss of HBsAg. The real-time PCR detected HBV DNA in 112 cases (89.6%). The mean levels of HBV DNA were 3.84, 4.10, and 3.31 log copies/ml in the three groups, respectively (P <0.01). Ninety-five percent of inactive HBsAg carriers showed levels of HBV DNA lower than 6×104 copies/ml. In conclusion, we showed different levels of HBV DNA exactly in three groups during nonreplicative phases. We suggest that the cutoff level of HBV DNA in inactive HBsAg carriers should be readjusted to a lower level in future studies.


Nonreplicative phase Inactive HBsAg carriers HBsAg loss Hepatitis B virus DNA Real-time PCR 


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Copyright information

© Springer Science&#x002B;Business Media, Inc. 2006

Authors and Affiliations

  • Hyung Joon Yim
    • 1
  • Kwan Soo Byun
    • 1
    • 4
  • Yun Jung Chang
    • 1
  • Yeon Seok Suh
    • 1
  • Jong Eun Yeon
    • 1
  • Chang Hong Lee
    • 1
  • Jung Ah Kwon
    • 2
  • Wangdon Yoo
    • 3
  • Soo-Ok Kim
    • 3
  • Sun Pyo Hong
    • 3
  1. 1.Department of Internal MedicineKorea University College of MedicineSeoulKorea
  2. 2.Department of Laboratory MedicineKorea University College of MedicineSeoulKorea
  3. 3.GeneMatrix Inc.SeoulKorea
  4. 4.Department of Internal MedicineKorea University Guro Hospital, 97 Gurodong-GilSeoulKorea

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