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Digestive Diseases and Sciences

, Volume 51, Issue 4, pp 775–778 | Cite as

Successful Treatment of Helicobacter Pylori-Negative Gastric MALT Lymphoma With Rituximab

  • Nadeem Chaudhary
  • Howard Ozer
  • David Huard
  • Stan Lightfoot
  • Sikandar Mesiya
Esophageal, Gastric, and Duodenal Disorders

Abstract

Helicobacter pylori infection is strongly associated with low-grade gastric lymphoma, commonly known as mucosa-associated lymphoid tissue (MALT) lymphoma. H. pylori eradication leads to complete remission in 80% of early stage MALT lymphomas. The treatment for early stage H. pylori-negative gastric MALT lymphoma is evolving. Rituximab, a chimeric anti-CD20 antibody, has shown response rates of approximately 50% with minimal toxicity in patients with B-cell non-Hodgkin lymphoma. We describe herein the clinical, endoscopic, and histologic features of a patient with H. pylori-negative gastric MALT lymphoma treated successfully with rituximab.

Key Words

gastric mucosal associated lymphoid tissue (MALT) lymphoma Helicobacter pylori (H. pylorirituximab 

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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Nadeem Chaudhary
    • 1
  • Howard Ozer
    • 1
  • David Huard
    • 2
  • Stan Lightfoot
    • 3
  • Sikandar Mesiya
    • 4
    • 5
  1. 1.Divisions of Gastroenterology and Oncology, Department of MedicineUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  2. 2.Divisions of Gastroenterology and Oncology, Department of RadiologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  3. 3.Divisions of Gastroenterology and Oncology, Department of PathologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  4. 4.Digestive Disease Specialists Inc.Oklahoma CityUSA
  5. 5.Digestive Disease Specialists Inc.Midwest City

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