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Digestive Diseases and Sciences

, Volume 51, Issue 4, pp 706–710 | Cite as

Distribution of Common CARD15 Variants in Patients with Sporadic Crohn’s Disease: Cases from Turkey

  • F. Aytül Uyar
  • Hülya Över-Hamzaoğlu
  • Filiz Türe
  • Ahmet Gül
  • Nurdan Tözün
  • Güher Saruhan-Direskeneli
Inflammatory Bowel Disease

Abstract

Three common genetic variations, namely, R702W, G908R, and 1007fs, on CARD15 have been shown to increase the risk for Crohn’s disease (CD) in Caucasian populations. In this study the frequencies of these CARD15 variants were determined by genotyping in 56 patients with CD and 100 healthy ethnically matched controls from Turkey. Overall frequency of all three variants was 10.7% in CD patients, compared with 1.5% in controls (odds ratio [OR]: 7.9). Among them, the frequency of the G908R variant allele was 8% in CD cases, compared with 0% in controls (OR: 36.8). The allele frequencies of three CD-related CARD15 variants were considerably lower in the control group compared to the reported Caucasian populations. Among the described CARD15 variants, G908R confers an increased susceptibility to CD, whereas the more frequently reported associations in Europeans with R702W and 1007fs are not confirmed in this Turkish population.

Key Words

CARD15/NOD2 Crohn’s disease inflammatory bowel disease Turkey 

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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • F. Aytül Uyar
    • 1
    • 4
  • Hülya Över-Hamzaoğlu
    • 2
  • Filiz Türe
    • 2
  • Ahmet Gül
    • 3
  • Nurdan Tözün
    • 2
  • Güher Saruhan-Direskeneli
    • 1
  1. 1.Department of PhysiologyIstanbul UniversityIstanbulTurkey
  2. 2.Department of Gastroenterology, Medical SchoolMarmara UniversityIstanbulTurkey
  3. 3.Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of MedicineIstanbul UniversityIstanbulTurkey
  4. 4.Department of PhysiologyIstanbul Faculty of MedicineCapa, IstanbulTurkey

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