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Distribution of Common CARD15 Variants in Patients with Sporadic Crohn’s Disease: Cases from Turkey

  • Inflammatory Bowel Disease
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Abstract

Three common genetic variations, namely, R702W, G908R, and 1007fs, on CARD15 have been shown to increase the risk for Crohn’s disease (CD) in Caucasian populations. In this study the frequencies of these CARD15 variants were determined by genotyping in 56 patients with CD and 100 healthy ethnically matched controls from Turkey. Overall frequency of all three variants was 10.7% in CD patients, compared with 1.5% in controls (odds ratio [OR]: 7.9). Among them, the frequency of the G908R variant allele was 8% in CD cases, compared with 0% in controls (OR: 36.8). The allele frequencies of three CD-related CARD15 variants were considerably lower in the control group compared to the reported Caucasian populations. Among the described CARD15 variants, G908R confers an increased susceptibility to CD, whereas the more frequently reported associations in Europeans with R702W and 1007fs are not confirmed in this Turkish population.

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Authors and Affiliations

  1. Department of Physiology, Istanbul University, Istanbul, Turkey

    F. Aytül Uyar MD & Güher Saruhan-Direskeneli MD

  2. Department of Gastroenterology, Medical School, Marmara University, Istanbul, Turkey

    Hülya Över-Hamzaoğlu MD, Filiz Türe MSc & Nurdan Tözün MD

  3. Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Ahmet Gül MD

  4. Department of Physiology, Istanbul Faculty of Medicine, Capa, Istanbul, 34093, Turkey

    F. Aytül Uyar MD

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  1. F. Aytül Uyar MD
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  2. Hülya Över-Hamzaoğlu MD
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  3. Filiz Türe MSc
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  4. Ahmet Gül MD
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  5. Nurdan Tözün MD
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  6. Güher Saruhan-Direskeneli MD
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Correspondence to F. Aytül Uyar MD.

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Uyar, F.A., Över-Hamzaoğlu, H., Türe, F. et al. Distribution of Common CARD15 Variants in Patients with Sporadic Crohn’s Disease: Cases from Turkey. Dig Dis Sci 51, 706–710 (2006). https://doi.org/10.1007/s10620-006-3195-y

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  • DOI: https://doi.org/10.1007/s10620-006-3195-y

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