Digestive Diseases and Sciences

, Volume 51, Issue 3, pp 466–470 | Cite as

Mild Whole-Body Heat Stress Alters Retinoid Metabolism in the Rat Small Intestine

  • Prabhu Ramamoorthy
  • Simmy Thomas
  • Anup Ramachandran
  • Kunissery A. Balasubramanian
Intestinal Diseases and Irritable Bowel Syndrome


Mild heat treatment can modulate metabolism and prevent stress-induced alterations in cells and tissues. Retinoids are known to influence cellular metabolism and are essential for growth and differentiation, particularlepithelial tissue. This study examines the effect of mild heat treatment on retinoid alterations in enterocytes in the rat small intestine. Heat treatment changed the differentiation pattern of enterocytes along the villus-crypt axis, accompanied by increases in retinol, retinaldehyde, and retinoic acid in proliferating crypt cells. Activities of retinoid metabolizing enzymes such as retinaldehyde oxidase and retinaldehyde reductase were also increased. These results suggest that mild heat treatment can alter retinoid metabolism in the small intestine, which might influence epithelial cell proliferation and differentiation.

Key Words

heat treatment intestine proliferation differentiation retinoid 


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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Prabhu Ramamoorthy
    • 1
  • Simmy Thomas
    • 1
  • Anup Ramachandran
    • 1
  • Kunissery A. Balasubramanian
    • 1
    • 2
  1. 1.The Wellcome Trust Research Laboratory, Department of Gastrointestinal SciencesChristian Medical CollegeVelloreIndia
  2. 2.The Wellcome Trust Research Laboratory, Department of Gastrointestinal SciencesChristian Medical CollegeVelloreIndia

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