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Distribution of HCV Genotypes in Patients with End-Stage Renal Disease According to Type of Dialysis Treatment

  • Haldun Selcuk
  • Mehmet Kanbay
  • Murat Korkmaz
  • Gurden Gur
  • Ali Akcay
  • Hande Arslan
  • Nurhan Ozdemir
  • Ugur Yilmaz
  • Sedat Boyacioglu
Original Paper

Abstract

The objective of this study was to investigate the effects of types of dialysis treatments on hepatitis C virus infection and the epidemiologic properties of hepatitis C virus (HCV) infection at three Baskent University hospitals, in Ankara, Adana, and Izmir, Turkey, in 655, 326, and 118 patients with end-stage renal disease, respectively. One hundred thirty patients with HCV viremia among 271 patients with end-stage renal disease seropositive for HCV were included in this cross-sectional study. HCV RNA-positive patients were classified according to the renal replacement therapies (hemodialysis or continuous ambulatory peritoneal dialysis), and viral load, transaminase levels, and distribution of genotypes were compared between these subgroups. In the continuous ambulatory peritoneal dialysis group, 26 of 165 patients (16%) were serum anti-HCV positive, and 11 of 26 patients (42%) were serum HCV RNA positive. Twenty-six percent of the patients undergoing hemodialysis were anti-HCV positive, and 49% were HCV RNA positive. The prevalence of genotype 1b was 68% and 73% for patients in the continuous ambulatory peritoneal dialysis and hemodialysis groups, respectively. No significant differences were found between the genotype 1b and the non-1b groups or between different dialysis types with regard to age and sex and serum aspartate transaminase, alanine aminotransferase, and HCV RNA levels. We conclude that HCV seropositivity may differ between different types of dialysis treatments, although viral load and genotypes may be similar in persons with end-stage renal disease and those without.

Keywords

End-stage renal disease Continuous ambulatory peritoneal dialysis Hemodialysis Viral load 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Haldun Selcuk
    • 1
  • Mehmet Kanbay
    • 2
  • Murat Korkmaz
    • 1
  • Gurden Gur
    • 1
  • Ali Akcay
    • 3
  • Hande Arslan
    • 4
  • Nurhan Ozdemir
    • 3
  • Ugur Yilmaz
    • 1
  • Sedat Boyacioglu
    • 1
  1. 1.Department of GastroenterologyBaskent University School of MedicineAnkaraTurkey
  2. 2.Department of Internal MedicineBaskent University School of MedicineAnkaraTurkey
  3. 3.Department of NephrologyBaskent University School of MedicineAnkaraTurkey
  4. 4.Department of Infectious DiseaseBaskent University School of MedicineAnkaraTurkey

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