Heparin and Insulin in the Treatment of Hypertriglyceridemia-Induced Severe Acute Pancreatitis
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Acute pancreatitis (AP) has been defined as the presence of a consistent clinical history and physical examination supported by serum amylase elevated to at least three times the upper limit of normal and positive pancreatic imaging. Severe pancreatitis has been defined as an APACHE II score ≥8 or a Ranson score ≥2 .
More than 75% of patients with hypertriglyceridemia-induced pancreatitis are either chronic alcoholics or uncontrolled diabetics. Hypertriglyceridemia may be primary (as seen in types I, IV, and V hyperlipoproteinemia) or secondary to diabetes mellitus, alcoholism, pregnancy, obesity, or use of certain drugs. Hypertriglyceridemia is thought to be the cause in 1% to 4% of patients with pancreatitis [2, 3].
Heparin and insulin stimulate lipoprotein lipase activity [4, 5]. Therefore, they reduce serum triglyceride levels. However, heparin and insulin’s efficacy in treatment of hypertriglyceridemia-induced acute pancreatitis is not well established. We report a patient...
Key WordsHypertriglyceridemia Acute pancreatitis Heparin Insulin