Digestive Diseases and Sciences

, Volume 50, Issue 11, pp 2178–2182 | Cite as

Inverse Dose Effect of Pretest Dietary Lactose Intake on Breath Hydrogen Results and Symptoms in Lactase Nonpersistent Subjects

  • Andrew Szilagyi
  • Paula Malolepszy
  • Samara Yesovitch
  • Usha Nathwani
  • Christina Vinokuroff
  • Albert Cohen
  • Xiaoqing Xue


The aim of this study was to determine a relationship between pretest intake of lactose and outcome of lactose breath hydrogen test. Patients presented at a testing laboratory participated in the study. A 3-hour breath hydrogen, 50-g lactose challenge was carried out. Results were tabulated and patients completed a 3-day recall diet questionnaire. Daily lactose intake was independently calculated and was associated with breath hydrogen and total symptom score. Statistical analysis used Spearman's correlation, Mann-Whitney U-test and χ2 or Fisher exact test. Of 118 patients, 50% were lactose maldigesters. In these patients, measured breath hydrogen and symptom scores were significantly higher in the lowest intake group (< 5 g/d) than in the highest intake group (> 20 g/d) (P < .05). In the presumed lactose digesters, 59% experienced some symptoms during testing for unclear reasons. Pretest dietary intake of lactose inversely affects results of breath hydrogen.

Key Words

dietary effects lactose breath hydrogen test 


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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Andrew Szilagyi
    • 1
    • 4
  • Paula Malolepszy
    • 1
  • Samara Yesovitch
    • 1
  • Usha Nathwani
    • 2
  • Christina Vinokuroff
    • 2
  • Albert Cohen
    • 1
  • Xiaoqing Xue
    • 3
  1. 1.Division of Gastroenterology, Department of Medicine, Sir Mortimer B. Davis—Jewish General HospitalMcGill UniversityMontrealCanada
  2. 2.Department of Dietetics, Sir Mortimer B. Davis—Jewish General HospitalMcGill UniversityMontrealCanada
  3. 3.Department of Emergency Medicine, Sir Mortimer B. Davis—Jewish General HospitalMcGill UniversityMontrealCanada
  4. 4.Division of Gastroenterology, Department of MedicineSir Mortimer B. Davis—Jewish General HospitalMontrealCanada

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