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Potentiation of Acetaminophen Hepatotoxicity by Phenytoin, Leading to Liver Transplantation

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Abstract

We report the case of a 22-year-old man who developed fulminant hepatic failure 3 days after an intentional acetaminophen overdose. The patient had a history of a seizure disorder for which he was taking phenytoin. The acetaminophen level at presentation was in the “nontoxic” range. Emergent liver transplantation was performed 4 days after the ingestion. This is the first reported case of successful liver transplantation for acetaminophen-induced fulminant hepatic failure in the setting of phenytoin therapy.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatobiliary Diseases, Department of Surgery, and Division of Liver Transplant Surgery, Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York, USA

    Scott M. Suchin, David C. Wolf, Young Lee, Gita Ramaswamy, Patricia A. Sheiner, Marcelo Facciuto, Michael R. Marvin, Leona Kim-schluger & Edward Lebovics

  2. 178 Lyons Road, Scarsdale, New York, 10583, USA

    Scott M. Suchin

Authors
  1. Scott M. Suchin
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  2. David C. Wolf
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  3. Young Lee
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  4. Gita Ramaswamy
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  5. Patricia A. Sheiner
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  6. Marcelo Facciuto
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  7. Michael R. Marvin
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  8. Leona Kim-schluger
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  9. Edward Lebovics
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Correspondence to Scott M. Suchin.

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Suchin, S.M., Wolf, D.C., Lee, Y. et al. Potentiation of Acetaminophen Hepatotoxicity by Phenytoin, Leading to Liver Transplantation. Dig Dis Sci 50, 1836–1838 (2005). https://doi.org/10.1007/s10620-005-2947-4

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  • DOI: https://doi.org/10.1007/s10620-005-2947-4

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