Digestive Diseases and Sciences

, Volume 50, Issue 9, pp 1611–1615 | Cite as

Acid Perfusion Test: A Useful Test for Evaluating Esophageal Acid Sensitivity

  • Alistair L. King
  • Angela Anggiansah
  • Roy Anggiansah
  • Terry Wong


The acid perfusion test (APT) is a test of esophageal acid sensitivity. In gastroesophageal reflux disease (GERD), the APT has largely been superseded by indexes derived from 24-hr esophageal pH monitoring: symptom index (SI), symptom sensitivity index (SSI), and symptom association probability (SAP). To evaluate the role of APT in patients with GERD we compared values of SI, SSI, and SAP in 126 APT+ and 146 APT− patients. Median values for SI, SSI, and SAP were higher in the APT+ compared with the APT− group (P < 0.001). More patients had a positive SI, SSI, and SAP in the APT+ compared with the APT– group (SI, P < 0.0001; SSI and SAP, P < 0.001). Patients with a negative APT were unlikely to have symptoms caused by acid reflux (negative predictive value, 86%). APT may be useful in detecting acid sensitivity in patients who do not report symptoms on 24-hr esophageal pH monitoring.


acid perfusion test Bernstein test gastroesophageal reflux disease esophageal acid sensitivity pH monitoring 


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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Alistair L. King
    • 1
    • 4
  • Angela Anggiansah
    • 2
  • Roy Anggiansah
    • 2
  • Terry Wong
    • 3
  1. 1.Department of GastroenterologyHemel Hempstead General HospitalHerts
  2. 2.Oesophageal LaboratorySt Thomas’ HospitalLondonUK
  3. 3.Department of GastroenterologySt Thomas’ HospitalLondonUK
  4. 4.Department of GastroenterologyHemel Hempstead General HospitalHertsUK

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