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Clinical Utility of Videofluorography with Concomitant Tensilon Administration in the Diagnosis of Bulbar Myasthenia Gravis

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Abstract

Myasthenia gravis (MG) classically presents with ocular, bulbar, and predominantly proximal muscle weakness. Isolated bulbar symptoms occur in less than 25% of cases and can mimic stroke (1–3). If left untreated, MG can lead to significant morbidity and mortality, including myasthenic crisis and recurrent aspiration pneumonia. We describe a case of a 68-year-old man who presented with isolated bulbar symptoms. We used a novel approach to diagnosis which included a videofluorographic swallow study with concomitant Tensilon (edrophonium) injection.

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References

  1. Maher J, Grand’Maison F, Nicolle MW, et al.: Diagnostic difficulties in myasthenia gravis. Muscle Nerve 21:577–583, 1998

    Article  CAS  PubMed  Google Scholar 

  2. Sharp, HR, Degrip A, Mitchell DB, et al.: Bulbar presentations of myasthenia gravis in the elderly. J Laryngol Otol 115:1–3, 2001

    Article  CAS  PubMed  Google Scholar 

  3. Colton-Hudson A, Koopman WJ, Moosa T, et al.: Prospective assessment of the characteristics of dysphagia in myasthenia gravis. Dysphagia 17:147–151, 2002

    Article  PubMed  Google Scholar 

  4. Bucholz DW: Neurogenic dysphagia: What is the cause when the cause is not obvious? Dysphagia 9:245–255, 1994

    Article  PubMed  Google Scholar 

  5. Kleiner-Fisman G, Kott HS: Myasthenia gravis mimicking stroke in elderly patients. Mayo Clini Proc 73:1077–1078, 1998

    Article  CAS  Google Scholar 

  6. Haider-Ali AM, MacGregor FB, Stewert M: Myasthenia gravis presenting with dysphagia and postoperative ventilatory failure. J Laryngol Otol 112:1194–1195, 1998

    CAS  PubMed  Google Scholar 

  7. Vincent A, Palace J, Hilton-Jones D: Myasthenia gravis. Lancet 357:2122–2128, 2001

    Article  CAS  PubMed  Google Scholar 

  8. Boonyapisit K, Kaminski HJ, Ruff RL: Disorders of neuromuscular junction ion channels. Am J Med 106:97–113, 1999

    Article  CAS  PubMed  Google Scholar 

  9. Kokontis L, Gutmann L: Current treatment of neuromuscular diseases. Arch Neurol 57:939–943, 2000

    Article  CAS  PubMed  Google Scholar 

  10. Scuderi F, Marino M, Colonna L, et al.: Anti-P110 autoantibodies identify subtype of “seronegative” myasthenia gravis with prominent oculobulbar involvement. Lab Invest 82:1139, 2002

    CAS  PubMed  Google Scholar 

  11. Van der Bilt A, Weijnen FG, Bosman F, et al.: Controlled study of EMG activity of the jaw closers and openers during mastication in patients with myasthenia gravis. Eur J Oral Sci 109:160–164, 2001

    Article  CAS  PubMed  Google Scholar 

  12. Lo YL, Leoh TH, Tan YE, et al.: Repetitive hypoglossal nerve stimulation in myasthenia gravis. Clin Neurophysiol 113:1227–1230, 2002

    Article  CAS  PubMed  Google Scholar 

  13. Weijen FG, Kuks JBM, Van der Bilt A, et al.: Tongue force in patients with myasthenia gravis. Acta Neurol Scand 102:303–308, 2000

    Article  PubMed  Google Scholar 

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Correspondence to Joanne Robbins PhD.

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Schwartz, D.C., Waclawik, A.J., Ringwala, S.N. et al. Clinical Utility of Videofluorography with Concomitant Tensilon Administration in the Diagnosis of Bulbar Myasthenia Gravis. Dig Dis Sci 50, 858–861 (2005). https://doi.org/10.1007/s10620-005-2653-2

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  • DOI: https://doi.org/10.1007/s10620-005-2653-2

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