, Volume 70, Issue 6, pp 1707–1712 | Cite as

Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells

  • Gakuro Harada
  • Shiori Onoue
  • Chisato Inoue
  • Sakae Hanada
  • Yoshinori KatakuraEmail author
Short Communication


Delphinidin is an anthocyanidin commonly found in various fruits and vegetables. Delphinidin has been known to possess many functions, such as an antioxidant, and anti-inflammatory, anti-cancer and anti-muscular atrophy agent. In this study, we attempted to evaluate the effects of delphinidin on lipid accumulation in hepatocytes. The results showed that palmitic acid (PA)-induced cellular senescence in HepG2 cells and reduced the expression of SMARCD1, which is known to regulate senescence-associated lipid accumulation in hepatocytes. However, delphinidin-3-glucoside (D3 g) suppressed PA-induced senescence and reversed the expression of SMARCD1 to the level of untreated HepG2 cells. Consequently, D3 g inhibited PA-induced lipid accumulation through the restoration of the expression of SMARCD1 and fatty acid oxidation genes. Taken together, our results suggest that D3 g suppresses the lipid accumulation induced by hepatocyte senescence.


Delphinidin Senescence Lipid HepG2 SMARCD1 

Supplementary material

10616_2018_246_MOESM1_ESM.docx (52 kb)
Supplementary material 1 (DOCX 52 kb)


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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Graduate School of Systems Life SciencesKyushu UniversityFukuokaJapan
  2. 2.Graduate School of Bioresource and Bioenvironmental SciencesKyushu UniversityFukuokaJapan
  3. 3.Faculty of AgricultureKyushu UniversityFukuokaJapan

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