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Cytotechnology

, Volume 70, Issue 6, pp 1707–1712 | Cite as

Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells

  • Gakuro Harada
  • Shiori Onoue
  • Chisato Inoue
  • Sakae Hanada
  • Yoshinori KatakuraEmail author
Short Communication

Abstract

Delphinidin is an anthocyanidin commonly found in various fruits and vegetables. Delphinidin has been known to possess many functions, such as an antioxidant, and anti-inflammatory, anti-cancer and anti-muscular atrophy agent. In this study, we attempted to evaluate the effects of delphinidin on lipid accumulation in hepatocytes. The results showed that palmitic acid (PA)-induced cellular senescence in HepG2 cells and reduced the expression of SMARCD1, which is known to regulate senescence-associated lipid accumulation in hepatocytes. However, delphinidin-3-glucoside (D3 g) suppressed PA-induced senescence and reversed the expression of SMARCD1 to the level of untreated HepG2 cells. Consequently, D3 g inhibited PA-induced lipid accumulation through the restoration of the expression of SMARCD1 and fatty acid oxidation genes. Taken together, our results suggest that D3 g suppresses the lipid accumulation induced by hepatocyte senescence.

Keywords

Delphinidin Senescence Lipid HepG2 SMARCD1 

Supplementary material

10616_2018_246_MOESM1_ESM.docx (52 kb)
Supplementary material 1 (DOCX 52 kb)

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Graduate School of Systems Life SciencesKyushu UniversityFukuokaJapan
  2. 2.Graduate School of Bioresource and Bioenvironmental SciencesKyushu UniversityFukuokaJapan
  3. 3.Faculty of AgricultureKyushu UniversityFukuokaJapan

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