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Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

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Abstract

The purpose of the present study was to investigate the osteoprotective effects of soybean oil (SbO) and sesame oil (SO) in ovarictomized (OVX) rats. The results indicated that the OVX rats exhibited a significant decrease in Ca and P level in both serum and bone, the activities of the antioxidant enzymes SOD and CAT and the antioxidant biomarker GSH accompanied with a marked increase in the oxidative stress markers MDA and PC, the inflammatory indices (TNF-α, CRP levels, WBCs counts and ACP activity) in, both, bone and serum. Supplementating the diet of the OVX rats with SbO (15 % w/w) or SO (10 % w/w) for 2 months to resulted in modulation of the alterations in all tested parameters and succeeded to restore minerals, antioxidant enzymes, antioxidant biomarkers, oxidative stress markers, inflammatory indices, and WBCs counts. It could be concluded that the consumption of diets supplemented with SbO or SO might be useful for preventing bone loss caused by estrogen deficiency in ovariectomy status.

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Abbreviations

SbO:

Soybean oil

SO:

Sesame oil

OVX:

Ovariectomized

Ca:

Calcium

P:

Phosphorous

ACP:

Acid phosphatase

SOD:

Super oxide dismutase

CAT:

Catalase

GSH:

Glutathione

RBCs:

Red blood cells

MDA:

Malondialdehyde

PC:

Protein carbonyl

TNF:

Tumor necrosis factors

CRP:

C-reactive protein

WBCs:

White blood cells

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Authors and Affiliations

  1. Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt

    Azza M. El Wakf, Hanaa A. Hassan & Nermin S. Gharib

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  1. Azza M. El Wakf
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  2. Hanaa A. Hassan
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  3. Nermin S. Gharib
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Correspondence to Hanaa A. Hassan.

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El Wakf, A.M., Hassan, H.A. & Gharib, N.S. Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism. Cytotechnology 66, 335–343 (2014). https://doi.org/10.1007/s10616-013-9580-4

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