Advertisement

Cytotechnology

, Volume 65, Issue 5, pp 787–788 | Cite as

The anti-neoplastic effects of coumarin: an emerging concept

  • Shailendra Kapoor
Letter to the Editor

Abstract

The recent article by Liu et al. provided for highly interesting reading. Interestingly, recent data suggests that coumarin may exert significant anti-neoplastic effects in a number of systemic malignancies. Coumarin is also of clinical benefit in mammary malignancies. For instance, it attenuates the extent of extremity lymphedema following breast cancer surgery and radiation therapy. In one recent study, an almost 12.5 % decline in the volume of upper extremity lymphedema was noticed. As a result, quality of life is significantly improved. Similar attenuation of tumor growth has been seen in pulmonary malignancies. It mediates these anti-neoplastic effects by attenuating Bcl-2 expression within the tumor cells. On the other hand, Bax expression within the tumor cells is markedly accentuated. These changes have recently been confirmed in A549 cells.

Keywords

Coumarin Breast cancer Prostate cancer 

Notes

Conflict of interest

None.

References

  1. Burgos A, Alcaide A, Alcoba C, Azcona JM, Garrido J, Lorente C, Moreno E, Murillo E, Olsina-Pavia J, Olsina-Kissler J, Samaniego E, Serra M (1999) Comparative study of the clinical efficacy of two different coumarin dosages in the management of arm lymphedema after treatment for breast cancer. Lymphology 32:3–10Google Scholar
  2. Liu X, Chen L, Sun F, Zhang G (2012) Enhanced suppression of proliferation and migration in highly-metastatic lung cancer cells by combination of valproic acid and coumarin-3-carboxylic acid and its molecular mechanisms of action. Cytotechnology. doi: 10.1007/s10616-012-9513-7
  3. Marshall ME, Butler K, Cantrell J, Wiseman C, Mendelsohn L (1989) Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study. Cancer Chemother Pharmacol 24:65–66CrossRefGoogle Scholar
  4. Musa MA, Badisa VL, Latinwo LM, Patterson TA, Owens MA (2012) Coumarin-based benzopyranone derivatives induced apoptosis in human lung (A549) cancer cells. Anticancer Res 32:4271–4276Google Scholar
  5. von Angerer E, Kager M, Maucher A (1994) Antitumour activity of coumarin in prostate and mammary cancer models. J Cancer Res Clin Oncol 120:S14–S16CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.MechanicsvilleUSA

Personalised recommendations