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Cytotechnology

, Volume 65, Issue 5, pp 785–786 | Cite as

Proanthocyanidin and its emerging anti-neoplastic effects: recent insights

  • Shailendra KapoorEmail author
Letter to Editor
  • 133 Downloads

Keywords

Androgen Receptor Nephrotoxicity Aberrant Crypt Focus Androgen Receptor Expression Urokinase Plasminogen Activator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Engelbrecht AM, Mattheyse M, Ellis B (2007) Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Cancer Lett 258:144–153CrossRefGoogle Scholar
  2. Hassan HA, Al-Rawi MM (2012) Grape seeds proanthocyanidin extract as a hepatic-reno-protective agent against gibberellic acid induced oxidative stress and cellular alterations. Cytotechnology. doi: 10.1007/s10616-012-9506-6
  3. Neuwirt H, Arias MC, Puhr M, Hobisch A, Culig Z (2008) Oligomeric proanthocyanidin complexes (OPC) exert anti-proliferative and pro-apoptotic effects on prostate cancer cells. Prostate 68:1647–1654CrossRefGoogle Scholar
  4. Nomoto H, Iigo M, Hamada H, Kojima S, Tsuda H (2004) Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis. Nutr Cancer 49:81–88CrossRefGoogle Scholar
  5. Prasad R, Vaid M, Katiyar SK (2012) Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo through induction of apoptosis and by targeting the PI3K/Akt pathway. PLoS One 7:e43064CrossRefGoogle Scholar
  6. Sayed AA (2009) Proanthocyanidin protects against cisplatin-induced nephrotoxicity. Phytother Res 23:1738–1741CrossRefGoogle Scholar
  7. Uchino R, Madhyastha R, Madhyastha H (2010) NF kappa B-dependent regulation of urokinase plasminogen activator by proanthocyanidin-rich grape seed extract: effect on invasion by prostate cancer cells. Blood Coagul Fibrinolysis 21:528–533CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.ChicagoUSA

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