, Volume 63, Issue 4, pp 407–413 | Cite as

In vitro cytotoxic potential of newly synthesized furo[3,2-c]pyran-4-one derivatives in cultured human lymphocytes

  • Halil Erhan EroğluEmail author
  • İrfan Koca
  • İsmail Yıldırım
Original Research


The in vitro cytotoxic potentials of Furo[3,2-c]pyran-4-one derivatives in human lymphocytes were investigated. Blood samples were obtained from six healthy donors, non-smoking volunteers, which were incubated and exposed to increasing concentrations (0.05, 0.1, 0.5, 1 and 2 mg/mL) of Furo[3,2-c]pyran-4-one derivatives which are methyl 2-methoxy-7-(4-methylbenzoyl)-6-(4-methylphenyl)-4-oxo-4H-furo[3,2-c]pyran-3-carboxylate (1a) and methyl 2-methoxy-7-(4-methoxybenzoyl)-6-(4-methoxyphenyl)-4-oxo-4H-furo[3,2-c]pyran-3-carboxylate (1b). Compounds 1a and 1b induced micronucleus, mitotic and replication indexes in human lymphocytes (1 and 2 mg/mL). The increases of micronucleus, mitotic and replication indexes show that compounds at high concentrations may become cytotoxic, genotoxic and carcinogenic.


Cytotoxic Furo[3,2-c]pyran-4-one Neo-tanshinlactone 


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Halil Erhan Eroğlu
    • 1
    Email author
  • İrfan Koca
    • 2
  • İsmail Yıldırım
    • 3
  1. 1.Department of Biology, Faculty of Science and ArtBozok UniversityYozgatTurkey
  2. 2.Department of Chemistry, Faculty of Science and ArtBozok UniversityYozgatTurkey
  3. 3.Department of Chemistry, Faculty of ScienceErciyes UniversityKayseriTurkey

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