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Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients: randomized, double-blind, placebo-controlled study

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Abstract

In this study, we evaluated the efficacy of Lactobacillus gasseri OLL2809 on endometriosis by the randomized, double-blind and placebo-controlled clinical study, especially against pain, which is one of the causative factors to decrease the quality of life. Sixty-six patients clinically diagnosed with endometriosis were enrolled in this study, 62 of which have successfully completed the trial. The tablets containing 100 mg of L. gasseri OLL2809 (active tablet, n = 29) or placebo tablets (n = 33) were ingested once a day for 12 weeks. Visual analog scale (VAS) of pain intensity at the menstrual period and verbal rating scale (VRS) of dysmenorrhea were significantly improved by the ingestion of the active tablets as compared with placebo tablets. There was no significant change of blood examination and biochemical examination of blood in the enrolled patients. Above results show that the tablet containing L. gasseri OLL2809 is effective on endometriosis, especially against menstrual pain and dysmenorrhea. Moreover, it was found that the tablet has no adverse effects. Therefore, it was suggested that the tablet containing L. gaserri OLL2809 contributes to improve the quality of life in the patients with endometriosis.

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Abbreviations

VAS:

Visual analog scale

VRS:

Verbal rating scale

NK:

Natural killer

IL:

Interleukin

QOL:

Quality of life

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Authors and Affiliations

  1. Food Science Institute, Meiji Dairies Corporation, 540 Naruda, Odawara, Kanagawa, 250-0862, Japan

    Hiroyuki Itoh, Masayuki Uchida, Toshihiro Sashihara & Zai-Si Ji

  2. Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, 200032, Shanghai, People’s Republic of China

    Ji Li, Qianjue Tang, Shuang Ni & Linyi Song

  3. Department of Food Science and Technology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-8510, Japan

    Shuichi Kaminogawa

Authors
  1. Hiroyuki Itoh
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  2. Masayuki Uchida
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  3. Toshihiro Sashihara
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  4. Zai-Si Ji
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  5. Ji Li
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  6. Qianjue Tang
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  7. Shuang Ni
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  8. Linyi Song
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  9. Shuichi Kaminogawa
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Correspondence to Toshihiro Sashihara.

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Itoh, H., Uchida, M., Sashihara, T. et al. Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients: randomized, double-blind, placebo-controlled study. Cytotechnology 63, 153–161 (2011). https://doi.org/10.1007/s10616-010-9326-5

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  • DOI: https://doi.org/10.1007/s10616-010-9326-5

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