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Enhancement of phagocytic activity of macrophage-like cells by pyrogallol-type green tea polyphenols through caspase signaling pathways

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Abstract

We investigated the phagocytosis-enhancing activity of green tea polyphenols, such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epicatechin (EC) catechin (+C) and strictinin, using VD3-differentiated HL60 cells. EGCG, EGC, ECG and strictinin, but not EC and +C, increased the phagocytic activity of macrophage-like cells, and a caspase inhibitor significantly inhibited phagocytic activities. These results suggest that the pyrogallol-type structure in green tea polyphenols may be important for enhancement of the phagocytic activity through caspase signaling pathways.

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Authors and Affiliations

  1. National Institute of Vegetable and Tea Science, NARO, 2769 Kanaya, Shimada, Shizuoka, 428-8501, Japan

    Manami Monobe, Kaori Ema, Yoshiko Tokuda & Mari Maeda-Yamamoto

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  1. Manami Monobe
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  2. Kaori Ema
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  3. Yoshiko Tokuda
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  4. Mari Maeda-Yamamoto
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Correspondence to Manami Monobe.

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Monobe, M., Ema, K., Tokuda, Y. et al. Enhancement of phagocytic activity of macrophage-like cells by pyrogallol-type green tea polyphenols through caspase signaling pathways. Cytotechnology 62, 201–203 (2010). https://doi.org/10.1007/s10616-010-9280-2

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  • DOI: https://doi.org/10.1007/s10616-010-9280-2

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