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Restraint stress up-regulates expression of zinc transporter Zip14 mRNA in mouse liver

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Abstract

The zinc concentration in the liver was significantly higher in mice at 12 h after the onset of restraint stress than that without stress. The IL-6 protein level in the serum was transiently elevated at 3 h after the onset of restraint stress, and the IL-6-responsive zinc transporter Zip14 mRNA in the liver was expressed markedly at 6 h. These results suggest that Zip14 plays a major role in the mechanism responsible for accumulation of zinc in the liver under restraint stress.

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Abbreviations

IL-6:

Interleukin-6

GAPDH:

Glyceraldehyde-3-phosphate dehydrogenase

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Acknowledgment

We thank Dr. Tomonori Iyoda for technical assistance of IL-6 ELISA.

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Authors and Affiliations

  1. Laboratory of Biosignals and Response, Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, 606-8502, Japan

    Takuya Ohashi, Moeko Chujo & Masaya Nagao

  2. Laboratory of Nutritional Science, Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan

    Tohru Matsui

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  1. Takuya Ohashi
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  2. Tohru Matsui
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  3. Moeko Chujo
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  4. Masaya Nagao
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Correspondence to Masaya Nagao.

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Ohashi, T., Matsui, T., Chujo, M. et al. Restraint stress up-regulates expression of zinc transporter Zip14 mRNA in mouse liver. Cytotechnology 57, 181–185 (2008). https://doi.org/10.1007/s10616-008-9148-x

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  • DOI: https://doi.org/10.1007/s10616-008-9148-x

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