, Volume 57, Issue 2, pp 181–185 | Cite as

Restraint stress up-regulates expression of zinc transporter Zip14 mRNA in mouse liver

  • Takuya Ohashi
  • Tohru Matsui
  • Moeko Chujo
  • Masaya Nagao
JAACT Special Issue


The zinc concentration in the liver was significantly higher in mice at 12 h after the onset of restraint stress than that without stress. The IL-6 protein level in the serum was transiently elevated at 3 h after the onset of restraint stress, and the IL-6-responsive zinc transporter Zip14 mRNA in the liver was expressed markedly at 6 h. These results suggest that Zip14 plays a major role in the mechanism responsible for accumulation of zinc in the liver under restraint stress.


Liver Restraint stress Serum Essential trace metal Zinc Zinc transporter 





Glyceraldehyde-3-phosphate dehydrogenase



We thank Dr. Tomonori Iyoda for technical assistance of IL-6 ELISA.


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Takuya Ohashi
    • 1
  • Tohru Matsui
    • 2
  • Moeko Chujo
    • 1
  • Masaya Nagao
    • 1
  1. 1.Laboratory of Biosignals and Response, Division of Integrated Life Science, Graduate School of BiostudiesKyoto UniversityKyotoJapan
  2. 2.Laboratory of Nutritional Science, Division of Applied Biosciences, Graduate School of AgricultureKyoto UniversityKyotoJapan

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