Adolescent Substance Use & Psychopathology: Interactive Effects of Cortisol Reactivity and Emotion Regulation
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How are emotional processes associated with the increased rates of substance use and psychological disorders commonly observed during adolescence? An index of emotion-related physiological arousal—cortisol reactivity—and subjective emotion regulation have both been independently linked to substance use and psychological difficulties among youth. The current study (N = 134 adolescents) sought to elucidate the interactive effects of cortisol reactivity following a stressful parent–child interaction task and self-reported emotion regulation ability on adolescents’ substance use and externalizing and internalizing behavior problems. Results revealed that adolescents with low levels of cortisol reactivity and high emotion regulation difficulties were more likely to use substances, and also had the highest parent-reported symptoms of oppositional defiant disorder. With respect to internalizing symptoms, high emotion-related physiological reactivity coupled with high emotion regulation difficulties were associated with higher self-reported major depression symptoms among youth. Findings reveal that different profiles of HPA axis arousal and emotion regulation are associated with substance use and symptoms of psychopathology among adolescents.
KeywordsAdolescence Emotion regulation Emotional arousal Emotional reactivity Cortisol Substance use Externalizing Internalizing
This work was carried out by a National Institute on Drug Abuse grant awarded to the fifth author (R01- DA033431). Please note that the content presented does not necessarily represent the official views of the National Institute on Drug Abuse, and that the funding sources had no other role other than financial support.
Compliance with Ethical Standards
Conflict of Interest
Jennifer A. Poon, Caitlin C. Turpyn, Amysue Hansen, Juliana Jacangelo and Tara M. Chaplin declare that they have no conflict of interest.
All procedures followed were in accordance with the ethical standards of the Institutional Review Boards at Yale University and George Mason University. Informed consent was obtained from all individual participants in the study.
No animal studies were carried out by the authors for this paper.
- Aiken, L. S., & West, S. G. (1991). Multiple regression: testing and interpreting interactions. Thousand Oaks, CA: Sage.Google Scholar
- Alink, L. R., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Mesman, J., Juffer, F., & Koot, H. M. (2008). Cortisol and externalizing behavior in children and adolescents: Mixed meta-analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior. Developmental Psychobiology, 50(5), 427–450.CrossRefPubMedGoogle Scholar
- American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.Google Scholar
- Cahalan, D., Cisin, I. H., & Crossley, H. M. (1969). American drinking practices: A national study of drinking behavior and attitudes. Monographs of the Rutgers Center of Alcohol Studies, 6, 260.Google Scholar
- Chassin, L., Collins, R. L., Ritter, J., Shirley, M. C., Zvolensky, M. J., & Kashdan, T. B. (2001). Vulnerability to substance use disorders across the lifespan. In Ingram & Prince (Eds.), Vulnerability to Psychopathology: Risk Across the Lifespan (pp. 165–172). New York: The Guilford Press.Google Scholar
- Cohen, J. (1998). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Erlbaum.Google Scholar
- Gadow, K. D., & Sprafkin, J. (1997). Child symptom inventory-4 norms manual. Stony Brook, NY: Checkmate Plus.Google Scholar
- Hankin, B. L., Badanes, L. S., Abela, J. R., & Watamura, S. E. (2010). Hypothalamic–pituitary–adrenal axis dysregulation in dysphoric children and adolescents: Cortisol reactivity to psychosocial stress from preschool through middle adolescence. Biological Psychiatry, 68(5), 484–490.CrossRefPubMedPubMedCentralGoogle Scholar
- Hayes, N. (Ed.). (2013). Doing qualitative analysis in psychology. Hove: Psychology Press.Google Scholar
- Hubbard, J. A., Smithmyer, C. M., Ramsden, S. R., Parker, E. H., Flanagan, K. D., Dearing, K. F., & Simons, R. F. (2002). Observational, physiological, and self-report measures of children’s anger: Relations to reactive versus proactive aggression. Child Development, 73(4), 1101–1118.CrossRefPubMedGoogle Scholar
- Johnston, L. D., O’Malley, P. M., Bachman, J. G., & Schulenberg, J. E. (2011). Monitoring the future national survey results on drug use, 1975–2010. Volume I, secondary school students. Institute for Social Research.Google Scholar
- Kaminer, Y., Bukstein, O., & Tarter, R. E. (1991). The teen-addiction severity index: Rationale and reliability. Substance Use and Misuse, 26(2), 219–226.Google Scholar
- Kandel, D. B., Johnson, J. G., Bird, H. R., Weissman, M. M., Goodman, S. H., Lahey, B. B., & Schwab-Stone, M. E. (1999). Psychiatric comorbidity among adolescents with substance use disorders: Findings from the MECA study. Journal of the American Academy of Child and Adolescent Psychiatry, 38(6), 693–699.CrossRefPubMedGoogle Scholar
- Kariyawasam, S. H., Zaw, F., & Handley, S. L. (2002). Reduced salivary cortisol in children with comorbid attention deficit hyperactivity disorder and oppositional defiant disorder. Neuroendocrinology Letter, 23(1), 45–48.Google Scholar
- Klimes-Dougan, B., Hastings, P. D., Granger, D. A., Usher, B. A., & Zahn-Waxler, C. (2001). Adrenocortical activity in at-risk and normally developing adolescents: Individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges. Development and Psychopathology, 13(3), 695–719.CrossRefPubMedGoogle Scholar
- Kovacs, M. (2004). Children’s depression inventory (CDI). Toronto: Multi-Health Systems Inc.Google Scholar
- Kring, A. M. (2008). Emotion disturbances as transdiagnostic processes in psychopathology. Handbook of emotion, 3, 691–705.Google Scholar
- McBurnett, K., Lahey, B. B., Frick, P. J., Risch, C., Loeber, R., Hart, E. L., & Hanson, K. S. (1991). Anxiety, inhibition, and conduct disorder in children: II. Relation to salivary cortisol. Journal of the American Academy of Child and Adolescent Psychiatry, 30(2), 192–196.CrossRefPubMedGoogle Scholar
- Reynolds, C. R., & Richmond, B. O. (1985). Revised Children’s Manifest Anxiety Scale. RCMAS Manual. Los Angeles: Western Psychological Services.Google Scholar
- van Goozen, S. H., Matthys, W., Cohen-Kettenis, P. T., Gispen-de Wied, C., Wiegant, V. M., & van Engeland, H. (1998). Salivary cortisol and cardiovascular activity during stress in oppositional-defiant disorder boys and normal controls. Biological Psychiatry, 43(7), 531–539.CrossRefPubMedGoogle Scholar
- Windle, M., Spear, L. P., Fuligni, A. J., Angold, A., Brown, J. D., Pine, D., & Dahl, R. E. (2008). Transitions into underage and problem drinking: Developmental processes and mechanisms between 10 and 15 years of age. Pediatrics, 121(Supplement 4), S273–S289.CrossRefPubMedPubMedCentralGoogle Scholar