Norlabdane Compounds Containing Thiosemicarbazone or 1,3-Thiazole Fragments: Synthesis and Antimicrobial Activity

New di-, tri-, tetra-, and pentanorlabdane compounds with thiosemicarbazone and 1,3-thiazole fragments were synthesized. Their antifungal and antibacterial activities were studied. The main advantages of this research were the available starting material, i.e., the natural labdane diterpenoid (–)-sclareol, which was isolated from renewable resources, and the high probability of biological activity combined with the low toxicity of these compounds because of their natural origin.

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Acknowledgment

We thank the World Federation of Scientists for financial support of scientific research on the Project “Synthesis, characterization and biological activity of di- and trinorlabdane compounds with 1,3-thiazole units.”

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Correspondence to A. N. Aricu.

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Translated from Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2021, pp. 84–92.

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Blaja, S.P., Lungu, L.V., Kuchkova, K.I. et al. Norlabdane Compounds Containing Thiosemicarbazone or 1,3-Thiazole Fragments: Synthesis and Antimicrobial Activity. Chem Nat Compd 57, 101–110 (2021). https://doi.org/10.1007/s10600-021-03292-3

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Keywords

  • norlabdane compounds
  • thiosemicarbazones
  • 1,3-thiazoles
  • synthesis
  • antimicrobial activity