A New Polyketide from the Mangrove-Derived Fungus Phomopsis sp. TJM1-5

A new polyketide, 9(E)-3-(5,8-dihydroxynon-3-en-1-yl)-5,6-dihydroxy-2,6-dimethylcyclohex-2-enone (1), and one known compound, 5-chloroisorotiorin (2), were isolated from the mangrove-derived fungus Phomopsis sp. TJM1-5. Their structures were determined by extensive NMR and MS analyses, while the absolute configurations of C-5 and C-6 were established based on experimental and calculated electronic circular dichroism spectra. Compound 2 was isolated from the genus of Phomopsis for the first time. Compounds 1 and 2 were evaluated for their antibacterial activity against five pathogenic bacteria.

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This work was supported by the Key Research and Development Program of Hainan Province (No. ZDYF2018183), National Natural Science Foundation of Hainan Province (No. 218MS045), the National Natural Science Foundation of China (Nos. 31760093 and 81660584), Guangxi Natural Science Foundation (No. 2016GXNSFBA380011), Program for Innovative Research Team in University (No. IRT-16R19), and Innovation Project of Postgraduate (No. Hys2018-75).

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Correspondence to Jing Xu or Cai-Juan Zheng.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2021, pp. 50–52.

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Zhu, XC., Chen, SJ., Huang, GL. et al. A New Polyketide from the Mangrove-Derived Fungus Phomopsis sp. TJM1-5. Chem Nat Compd 57, 59–62 (2021). https://doi.org/10.1007/s10600-021-03282-5

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  • Phomopsis sp.
  • polyketide
  • antibacterial activity