Synthesis of New Conjugates of Coumarins with Anabasine and Cytisine

Chemistry of Natural Compounds volume 57, pages9–13(2021)Cite this article

The reactions of cytisine with glycidyl ethers of 3-arylcoumarins were studied. A series of cytisine–coumarin conjugates were synthesized via regiospecific opening of the oxirane ring by cytisine. Methods for conjugating anabasine and cytisine with 3-arylcoumarins through a but-2-ynyl linker via reactions of propargyl ethers of 7-hydroxy- and 6-hydroxy-3-arylcoumarins with the alkaloids were proposed.

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Affiliations

  1. National University of Food Technologies, 68 Vladimirskaya St., Kiev, 01601, Ukraine

    S. P. Bondarenko, G. P. Mrug & M. S. Frasinyuk

  2. V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanskaya St., Kiev, 02094, Ukraine

    G. P. Mrug & M. S. Frasinyuk

  3. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan, 700170

    V. I. Vinogradova

Authors
  1. S. P. Bondarenko
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  2. G. P. Mrug
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  3. V. I. Vinogradova
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  4. M. S. Frasinyuk
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Correspondence to S. P. Bondarenko.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2021, pp. 12–15.

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Bondarenko, S.P., Mrug, G.P., Vinogradova, V.I. et al. Synthesis of New Conjugates of Coumarins with Anabasine and Cytisine. Chem Nat Compd 57, 9–13 (2021). https://doi.org/10.1007/s10600-021-03268-3

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Keywords

  • cytisine
  • anabasine
  • 3-arylcoumarin
  • glycidyl ether
  • propargyl ether