Skip to main content
SpringerLink
Log in

A New Polyketide-Derived Metabolite with PTP1B Inhibitory Activity from the Endophytic Fungus Pestalotiopsis neglecta

  • Published:
Chemistry of Natural Compounds Aims and scope

A new polyketide-derived metabolite, named neglectine A, was isolated from cultures of the endophytic fungus Pestalotiopsis neglecta. Its structure was elucidated by analysis of 1D and 2D spectroscopic data as well as MS. Neglectine A possessed a rare bis-tetrahydrofuran ring system and showed moderate activities against SHP1, CDC25B, and PTP1B, with IC50 value of 17.1 μg/mL, 24.0 μg/mL, and 6.7 μg/mL, respectively. It is important to note that neglectine A has exhibited significant selectivity between PTP1B and CDC25B, LAR, SHP1, and SHP2. This is the first time that neglectine A is reported to have significant PTP1B inhibitory action.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.

Similar content being viewed by others

References

  1. A. J. Barr, Future Med. Chem., 2, 1563 (2010).

    Article  CAS  Google Scholar 

  2. C. S. Jiang, L. F. Liang, and Y. W. Guo, Acta Pharm. Sin., 33, 1217 (2012).

    Article  CAS  Google Scholar 

  3. L. F. Liang, S. N. Du, K. Y. Huang, K. Li, and Y. Y. Fan, Chem. Nat. Compd., 54, 382 (2018).

    Article  CAS  Google Scholar 

  4. X. L. Yang, J. Z. Zhang, and D. Q. Luo, Nat. Prod. Rep., 29, 622 (2012).

    Article  CAS  Google Scholar 

  5. S. B. Toofanee and R. Dulymamode, Fungal Div., 11, 169 (2002).

    Google Scholar 

  6. K. Sakai, T. Suga, M. Iwatsuki, T. Chiren, K. Nonaka, T. Usui, Y. Asami, S. Omura, and K. Shicmi, J. Antibiot., 71, 1031 (2018).

    Article  CAS  Google Scholar 

  7. S. J. Li, X. Zhang, X. H. Wang, and C. Q. Zhao, Eur. J. Med. Chem., 156, 316 (2018).

    Article  CAS  Google Scholar 

  8. J. Xu, X. Yang, and Q. Lin, Fungal Divers., 66, 37 (2014).

    Article  Google Scholar 

  9. I. H. Hwang, D. C. Swenson, J. B. Gloer, and D. T. Wicklow, J. Nat. Prod., 79, 523 (2016).

    Article  CAS  Google Scholar 

  10. L. M. Scott, H. R. Lawrence, S. M. Sebti, N. J. Lawrence, and J. Wu, Curr. Pharm. Des.,16, 1843 (2010).

    Article  CAS  Google Scholar 

  11. C. Chen, M. M. Cao, S. Y. Zhu, C. C. Wang, F. Liang, L. L. Yan, and D. Q. Luo, Sci. Rep.,5, 17626 (2015).

    Article  CAS  Google Scholar 

Download references

Acknowledgment

This work was funded by the National Key Research and Development Program of China (2017YFD0201400 and 2017YFD0201401), National Natural Science Foundation of China (31672070), Changjiang Scholars and Innovative Research Team in University (IRT_15R16), and the High-Level Talents Programs of Hebei Province (GCC2014034).

Author information

Authors and Affiliations

  1. College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, 071002, Baoding, P. R. China

    Wen-Bin Gao, Li-Ping Han, Xiao-Fang Li, Jun Zhang & Du-Qiang Luo

  2. College of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, 071002, Baoding, P. R. China

    Fei-Xiang Xie

  3. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, 571101, Haikou, P. R. China

    Qing-Yun Ma & You-Xing Zhao

Authors
  1. Wen-Bin Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Li-Ping Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fei-Xiang Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Qing-Yun Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiao-Fang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jun Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. You-Xing Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Du-Qiang Luo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to You-Xing Zhao.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2019, pp. 910–912.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gao, WB., Han, LP., Xie, FX. et al. A New Polyketide-Derived Metabolite with PTP1B Inhibitory Activity from the Endophytic Fungus Pestalotiopsis neglecta. Chem Nat Compd 55, 1056–1058 (2019). https://doi.org/10.1007/s10600-019-02892-4

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-019-02892-4

Keywords

Search

Navigation