Sixteen tyrosol derivatives were synthesized and characterized by NMR and HR-MS. The antioxidant activity of those compounds was evaluated using four different assays. The results showed that some target compounds displayed better antioxidant activity than L-ascorbic acid and Trolox. Five target compounds exhibited more potent α-glucosidase inhibition activity (18.1–56.7 μM) than acarbose (60.9 μM). Eight target compounds showed some anticholinesterase activities.
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Acknowledgment
This work was supported by the Science and Technology Development Funds of Jilin Province (No. 20160520044JH) and the Science and Technology Projects of Administration of Traditional Chinese Medicine of Jilin Province (No. 2017110). In addition, Hao Zang and Peng Shen contributed equally to this work.
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2019, pp. 899–904.
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Zang, H., Shen, P., Xu, Q. et al. Synthesis and Biological Activities of Tyrosol Phenolic Acid Ester Derivatives. Chem Nat Compd 55, 1043–1049 (2019). https://doi.org/10.1007/s10600-019-02889-z
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DOI: https://doi.org/10.1007/s10600-019-02889-z