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Anti-Ache Benzylbenzofuran Derivatives from Silene conoidea

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Chemistry of Natural Compounds Aims and scope

A new benzylbenzofuran, named 5′,7-dihydroxy-6-propenyl-2-(11′,12′-dimethylpyran)-benzylbenzofuran (1), and seven known benzylbenzofuran derivatives (2–8) were isolated from Silene conoidea L. for the first time. The structures of compounds 1–8 were identified by their spectral data and reference data. Compounds 1–8 were evaluated for anti-acetylcholinesterase (AChE) activities for the first time. Compounds 1, 2, 5, and 6 showed anti-AChE activities with IC50 values ranging from 12.55–85.43 μM.

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Acknowledgment

This work was financially supported by the Key Scientific Research Project of Colleges and Universities in Henan Province (No. 19A350006), the National Natural Science Foundation of China (No. 81803843), the Standard Revision Research Project of National Pharmacopoeia Committee (No. 2018Z090), the Science and Technology Project of Jiangxi Health Commission (No. 20195648), the Science and Technology Project of Jiangxi Health Commission (No. 20195650), the Science and Technology Project of Jiangxi Provincial Department of Education (No. GJJ180662), the Science and Technology Project of Jiangxi Provincial Department of Education (No. GJJ180688), and the Scientific Research Project of First-class Discipline of Chinese Materia Medica of Jiangxi University of TCM (No. JXSYLXK-ZHYAO032).

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Correspondence to Qinge Ma.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2019, pp. 562–564.

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Wei, R., Ma, Q. & Zhong, G. Anti-Ache Benzylbenzofuran Derivatives from Silene conoidea. Chem Nat Compd 55, 654–657 (2019). https://doi.org/10.1007/s10600-019-02771-y

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