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Four Major Urinary Metabolites of Liquiritigenin in Rats and Their Anti-Platelet Aggregation Activity

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Chemistry of Natural Compounds Aims and scope

Urinary metabolites of liquiritigenin were investigated in rats after intravenous administration. Four major urinary metabolites, isoliquiritigenin (2), liquiritigenin-4′-O-β-D-glucuronide (3), liquiritigenin-7-O-β-Dglucuronide (4), and davidigenin-2′-O-β-D-glucuronide (5), were isolated from the urine of rats. Their structures were elucidated on the basis of extensive spectroscopic methods, among which 5 was a new compound. Compound 2 showed significant inhibition of platelet aggregation induced by ADP, whose 50% inhibitory concentration (IC50) value was 20.38 ± 1.68 μM.

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Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (Grant numbers 81403060 and 81202877).

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Authors and Affiliations

  1. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 300193, Tianjin, P. R. China

    Yuan-yuan Li, Long Yang, Xin Chai, Jun-jun Yang, Yue-fei Wang & Yan Zhu

  2. Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 300193, Tianjin, P. R. China

    Yuan-yuan Li, Long Yang, Xin Chai, Jun-jun Yang, Yue-fei Wang & Yan Zhu

Authors
  1. Yuan-yuan Li
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  2. Long Yang
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  3. Xin Chai
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  4. Jun-jun Yang
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  5. Yue-fei Wang
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  6. Yan Zhu
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Corresponding authors

Correspondence to Xin Chai or Yue-fei Wang.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2018, pp. 377–379.

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Li, Yy., Yang, L., Chai, X. et al. Four Major Urinary Metabolites of Liquiritigenin in Rats and Their Anti-Platelet Aggregation Activity. Chem Nat Compd 54, 443–446 (2018). https://doi.org/10.1007/s10600-018-2375-2

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  • DOI: https://doi.org/10.1007/s10600-018-2375-2

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