Heterocyclic Alkaloids as Antimicrobial Agents of Aspergillus fumigatus D Endophytic on Edgeworthia chrysantha
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Growing evidence indicates that endophytes are among the new prolific producers of bioactive natural products . In our screening of antimicrobial endophytes from Edgeworthia chrysantha Lindl., a traditional Chinese medicinal plant used to treat swelling of eye, ophthalmalgia, delacrimation, nephelium of eye, and nocturnal emission [2, 3, 4], the ethyl acetate extract of the fermentation broth of the endophytic strain D exhibited strong antimicrobial activities against pathogenic Escherichia coli, Staphyloccocus aureus, and Candida albicans . A follow-up bioassay-guided fractionation led to the isolation of five heterocyclic alkaloids (1–5) with potent antimicrobial activities.
The authors acknowledge financial support from the National Natural Science Foundation of China (Nos. 41776139 and 81773628), the National Key Research and Development Plan (No. 2017YFE0103100), the Zhejiang Natural Science Foundation of China (LY16H300007 and LQ14C200005), and Huahai Student Innovation Program of Zhejiang University of Technology (2015).