Chemistry of Natural Compounds

, Volume 54, Issue 2, pp 399–401 | Cite as

Antibacterial Indole Alkaloids and Anthraquinones from a Sewage-Derived Fungus Eurotium sp.

  • Dan Zhao
  • Fei Cao
  • Xiu-Jie Guo
  • Yun-Rui Zhang
  • Zengjun Kang
  • Hua-Jie Zhu

Eurotium, a common fungus closely related to human life, is adapted to high osmotic pressure and can adapt to a low water environment [1]. They are dominant microorganisms that are found during the molding process in the manufacture of Japanese Katsuobushi [2] and Chinese Fuzhuan brick-tea [3]. Eurotium sp. are a rich source of bioactive secondary metabolites, such as anthraquinones, benzaldehydes, and diketopiperazines [1]. Some of these metabolites possess antimicrobial [4], antitumor [5], anti-inflammatory [6], and cytotoxic activities [7], as well as antioxidant properties [5], and the ability to degrade pesticide residues [8], among others. Therefore, a comprehensive understanding of the characteristics and secondary metabolites of Eurotium would lay a foundation for the reasonable utilization of its resources. Herein, we report the isolation, structural characterization, and biological activities of these compounds.

On the basis of spectral data and by comparison with those...



This work was supported by the Natural Science Foundation of Hebei Province of China (No. B2017201059) and the National Natural Science Foundation of China (No. 41606174). Financial support from Hebei University is acknowledged. We thank Renee Mosi, PhD, from Liwen Bianji, Edanz Group China (, for editing the English text of a draft of this manuscript.


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Authors and Affiliations

  1. 1.Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical SciencesHebei UniversityBaodingP. R. China
  2. 2.Department of NeurologyAffiliated Hospital of Hebei UniversityBaodingP. R. China

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