Glycoside Flavonoids from Dracocephalum komarovii
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Previously, β-sitosterol, β-stigmasterol, diosmetin, chrysoeriol, cirsilineol, kaempferol 3-methyl ether, and luteolin-7-O-β-methylglucuronide were isolated and identified by us from the aerial part of Dracocephalum komarovii Lipsky (Lamiaceae) collected in Tashkent Oblast (Uzbekistan) .
In continuation of research on the chemical composition of the aerial part of D. komarovii , we chromatographed the alcohol extract over a column of silica gel (200–300 mesh, 250 g) with gradient elution by CHCl3–MeOH mixtures (9:1–1:1) to isolate five flavonoid glycosides. Each isolated compound was also rechromatographed over a column of Sephadex LH-20 with elution by MeOH–H2O (2:1) to afford five compounds 1 (11 mg), 2 (118 mg), 3 (4 mg), 4 (2.78 mg), and 5 (16 mg) that were identified as apigenin-7-O-glucoside (1) , luteolin-7-O-glucoside (2) , acacetin-7-O-glucoside (3) , luteolin-7-O-glucuronide (4) , and acacetin-7-O-[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside (5) . The...
The work was financially sponsored by the Foundations and Programs for International Scientific and Technical Collaboration Projects (Grant No. 2016YFE0120600) and the Central Asia Drug Research and Development Center of Chinese Academy of Sciences.