Chemical Constituents of the Stems of Spatholobus parviflorus and Their Cholinesterase Inhibitory Activity
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Spatholobus parviflorus (Fabaceae), locally known as “Tao Pun Sai,” is a strong and woody climber. It is widely distributed in many parts of Thailand. An ethnobotanical use of this species by tribesmen in the North is as a medicinal plant to treat rheumatism, anemia, and other diseases. In previous work, the active constituents of the leaves of S. parviflorus were reported . However, to our knowledge the chemical constituents of S. parviflorus stems have not been reported up to now. The stem extract of S. parviflorus was fractionated by a combination of silica gel column chromatography and centrifugal thin-layer chromatography to afford stigmasterol (1) , (6aR,11aR)-medicarpin (2) , 8-O-methylretusin (3) , formononetin (4) , biochanin A (5) , 7,4′-dihydroxy-8-methoxyisoflavone (6) , daidzein (7) , trans and cis-4-hydroxymelleins (8 and 9) , and coumestrol (10) , which were interpreted by spectroscopic analysis, particularly NMR and MS and coincided well...
The authors are grateful to the Graduate School of Chulalongkorn University for a Postdoctoral Fellowship (Ratchadaphiseksomphot Endowment Fund) to JS and the Thailand Research Fund via Directed Basic Research Grant (Grant No. DBG 5980001) for partial financial support. We also thank Dr. Christopher Smith of the Department of Chemistry, Faculty of Science, Chulalongkorn University, for his editorial comments.