Studies Towards the Synthesis of the Core of Endiandric Acid H
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In the presence of a CuBr·SMe2 catalytic system, a very simple and efficient approach for the synthesis of the key precursor of the core of endiandric acids starting from the readily and abundantly available 3-butyn-1-ol in five linear steps with an overall yield of 40% was developed.
Keywordsendiandric acids H synthesis CuBr·SMe2 natural products
This work was supported by the National Natural Science Foundation of China (21502073), the Natural Science Foundation of Jiangsu Province (Grant No. BK 20150465), and the Collaborative Innovation Center of Ship Technology in Jiangsu Colleges and Universities/Marine Equipment and Technology Institute for Jiangsu University of Scince and Technology.
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