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Chemistry of Natural Compounds

, Volume 54, Issue 2, pp 270–273 | Cite as

Furan-2-Carboxylic Acids from the Roots of Nicotiana tabacum and their Bioactivities

  • Yu-Ping Wu
  • Guang-Hui Kong
  • Wei Li
  • Ling Ye
  • Dan-Yu Tang
  • Feng-Mei Zhang
  • Pei He
  • Zhi-Hua Liu
  • Qin-Peng Shen
  • Zhang-Yuan Xia
  • Chun-Bo Liu
Article

Two new furan-2-carboxylic acids, 5-(3-hydroxy-5-(hydroxymethyl)-4-methoxyphenyl)-3-methylfuran-2-carboxylic acid (1) and 5-(4-hydroxy-5-methoxy-2-methylphenyl)-3-methylfuran-2-carboxylic acid (2), together with two known furan-2-carboxylic acids (3 and 4) were isolated from the roots of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (TMV) and cytotoxicity activities. The results revealed that compounds 1 and 2 showed high anti-TMV activity with inhibition rate of 35.8 and 32.6%. These rates are close to that of positive control. Compounds 1 and 2 also showed moderate to weak inhibitory activities against some tested human tumor cell lines with IC50 values in the range of 1.5–6.0 μM.

Keywords

furan-2-carboxylic acid Nicotiana tabacum anti-tobacco mosaic virus activities cytotoxicity activities 

Notes

Acknowledgment

This project was supported by the National Natural Science Foundation of China (Nos. 21302164, 31460144, and 21562044) and the Applied Fundamental Foundation of Yunnan Province (No. 2013FB097).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Yu-Ping Wu
    • 1
    • 2
  • Guang-Hui Kong
    • 1
  • Wei Li
    • 1
  • Ling Ye
    • 2
  • Dan-Yu Tang
    • 2
  • Feng-Mei Zhang
    • 2
  • Pei He
    • 2
  • Zhi-Hua Liu
    • 2
  • Qin-Peng Shen
    • 2
  • Zhang-Yuan Xia
    • 1
  • Chun-Bo Liu
    • 2
  1. 1.Yunnan Academy of Tobacco Agricultural SciencesKunmingP. R. China
  2. 2.Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., LtdKunmingP. R. China

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