Chemistry of Natural Compounds

, Volume 54, Issue 2, pp 253–256 | Cite as

Four Verrucosidin Derivatives Isolated from the Hydrothermal Vent Sulfur-Derived Fungus Penicillium sp. Y-50-10

  • Chengqian Pan
  • Yutong Shi
  • Bibi Nazia Auckloo
  • Chen-Tung Arthur Chen
  • Xuegang Chen
  • Xiaodan Wu
  • Bin Wu

Four verrucosidin derivatives, penicyrone (1), norpenicyrone (2), methyl norpenicyrone (3), and methyl penicyrone (4) were isolated from the hydrothermal vent sulfur-derived fungus Penicillium sp. Y-50-10. Compounds 1–4 were obtained as a mixture of two epimers. Compounds 2–4 have been proved to be new secondary metabolites. The chemical structures were determined by comparing with literature data and HR-MS and 2D NMR spectroscopic analysis. The migration of the double bond from C8=C9 to C7=C8 in compounds 1–4 allowed the assignment of a rearranged verrucosidin skeleton. Compounds 1–4 showed activity against B. subtilis, with MIC values of 32 μg/mL.


marine fungus Penicillium sp. penicyrone 



This work was supported by NSFC (Nos. 81273386 and 81573306).


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Chengqian Pan
    • 1
  • Yutong Shi
    • 1
  • Bibi Nazia Auckloo
    • 1
  • Chen-Tung Arthur Chen
    • 2
  • Xuegang Chen
    • 1
  • Xiaodan Wu
    • 3
  • Bin Wu
    • 1
  1. 1.Ocean CollegeZhejiang UniversityHangzhouP. R. China
  2. 2.Department of OceanographyNational Sun Yat-sen UniversityKaohsiungP. R. China
  3. 3.Center of Analysis and MeasurementZhejiang UniversityHangzhouP. R. China

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