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Phthalides and Other Metabolites from Roots of Ligusticum wallichii

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Chemistry of Natural Compounds Aims and scope

A new phthalide that was identified using NMR and mass spectral data as (±)-3-methoxysedanenolide (1) and the nine known compounds sedanenolide (2), Z-ligustilide (3), Z-butylidenephthalide (4), methyl ferulate (5), trans-ferulic (6) and trans-isoferulic acids (7), falcarindiol (8), β-sitosterol (9), and daucosterol (10) were isolated from the MeOH extract of roots of Ligusticum wallichii. Compounds 7 and 8 exhibited high inhibitory activity against NO formation in RAW264.7 cells.

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Acknowledgment

The work was supported financially by the Vietnam Academy of Science and Technology Grant VAST.UDCN.05/14-16.

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Authors and Affiliations

  1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi, Cau Giay, Vietnam

    Tran Huu Giap, Nguyen Anh Dung, Ha Thi Thoa, Nguyen Hai Dang, Nguyen Tien Dat, Nguyen Thi Minh Hang, Pham Van Cuong, Nguyen Van Hung, Chau Van Minh & Le Nguyen Thanh

  2. G. B. Elyakov Pacific Institute of Bioorganic Chemistry, 159 100-Let Vladivostoku Prosp, Vladivostok, Russian Federation, 690022

    N. P. Mishchenko & S. A. Fedoreev

Authors
  1. Tran Huu Giap
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  2. Nguyen Anh Dung
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  3. Ha Thi Thoa
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  4. Nguyen Hai Dang
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  5. Nguyen Tien Dat
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  6. Nguyen Thi Minh Hang
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  7. Pham Van Cuong
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  8. Nguyen Van Hung
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  9. Chau Van Minh
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  10. N. P. Mishchenko
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  11. S. A. Fedoreev
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  12. Le Nguyen Thanh
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Corresponding author

Correspondence to Le Nguyen Thanh.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2018, pp. 32–34. Original article submitted April 11, 2017.

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Giap, T.H., Dung, N.A., Thoa, H.T. et al. Phthalides and Other Metabolites from Roots of Ligusticum wallichii. Chem Nat Compd 54, 34–37 (2018). https://doi.org/10.1007/s10600-018-2253-y

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  • DOI: https://doi.org/10.1007/s10600-018-2253-y

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