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Chemistry of Natural Compounds

, Volume 54, Issue 1, pp 34–37 | Cite as

Phthalides and Other Metabolites from Roots of Ligusticum wallichii

  • Tran Huu Giap
  • Nguyen Anh Dung
  • Ha Thi Thoa
  • Nguyen Hai Dang
  • Nguyen Tien Dat
  • Nguyen Thi Minh Hang
  • Pham Van Cuong
  • Nguyen Van Hung
  • Chau Van Minh
  • N. P. Mishchenko
  • S. A. Fedoreev
  • Le Nguyen Thanh
Article

A new phthalide that was identified using NMR and mass spectral data as (±)-3-methoxysedanenolide (1) and the nine known compounds sedanenolide (2), Z-ligustilide (3), Z-butylidenephthalide (4), methyl ferulate (5), trans-ferulic (6) and trans-isoferulic acids (7), falcarindiol (8), β-sitosterol (9), and daucosterol (10) were isolated from the MeOH extract of roots of Ligusticum wallichii. Compounds 7 and 8 exhibited high inhibitory activity against NO formation in RAW264.7 cells.

Keywords

Ligusticum wallichii phthalides 

Notes

Acknowledgment

The work was supported financially by the Vietnam Academy of Science and Technology Grant VAST.UDCN.05/14-16.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Tran Huu Giap
    • 1
  • Nguyen Anh Dung
    • 1
  • Ha Thi Thoa
    • 1
  • Nguyen Hai Dang
    • 1
  • Nguyen Tien Dat
    • 1
  • Nguyen Thi Minh Hang
    • 1
  • Pham Van Cuong
    • 1
  • Nguyen Van Hung
    • 1
  • Chau Van Minh
    • 1
  • N. P. Mishchenko
    • 2
  • S. A. Fedoreev
    • 2
  • Le Nguyen Thanh
    • 1
  1. 1.Institute of Marine BiochemistryVietnam Academy of Science and TechnologyHanoiVietnam
  2. 2.G. B. Elyakov Pacific Institute of Bioorganic ChemistryVladivostokRussian Federation

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