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Chemistry of Natural Compounds

, Volume 53, Issue 3, pp 555–556 | Cite as

Antiproliferative Prenylated Xanthones from the Pericarps of Garcinia mangostana

  • You-Min Ying
  • Kai-Ming Yu
  • Tian-Song Lin
  • Lie-Feng Ma
  • Ling Fang
  • Jian-Biao Yao
  • Bing-Yu Chen
  • Ru-Wei Wang
  • Wei-Guang Shan
  • Zhen Wang
  • Zha-Jun Zhan
Article

Xanthones are a kind of natural products bearing a unique tricyclic aromatic system (C6–C3–C6) [1]. The structural diversities of these compounds arise mainly from the different substitutions of the A and B rings in the skeleton, with isoprene, methoxyl, and hydroxyl groups, being the most frequently occurring substituents. Accordingly, xanthones can be classied into several groups including simple oxygenated xanthones, prenylated xanthones, xanthone glycosides, and xanthonolignoids based on these substituents [2]. In recent years, xanthones have been identified as promising bioactive compounds with wide ranging and potentially usefull biological activities such as anticancer, anti-HIV, anti-inflammatory, antibacterial, and neurotrophic activities [3]. Garcinia mangostana is a tropical fruit native to Southeast Asia that has long been noted for its medicinal and health promoting properties [4]. Compared to the other species in the genus Garcinia, G. mangostanahas captured the most...

Keywords

Column Chromatography CH3OH EtOAc Isoprene Xanthone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

This work was financially supported by the Traditional Chinese Medicine Outstanding Young Talent Foundation of Zhejiang Province (2014ZQ005) and the Traditional Chinese Medicine Scientific Research Foundation of Zhejiang Province (2014ZB007).

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • You-Min Ying
    • 1
    • 2
  • Kai-Ming Yu
    • 1
  • Tian-Song Lin
    • 1
  • Lie-Feng Ma
    • 1
  • Ling Fang
    • 2
  • Jian-Biao Yao
    • 2
  • Bing-Yu Chen
    • 3
  • Ru-Wei Wang
    • 2
  • Wei-Guang Shan
    • 1
  • Zhen Wang
    • 3
  • Zha-Jun Zhan
    • 1
  1. 1.College of Pharmaceutical ScienceZhejiang University of TechnologyHangzhouP. R. China
  2. 2.Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical TechnologyZhejiang CONBA Pharmaceutical Co., LtdHangzhouP. R. China
  3. 3.Institute of Molecular Medicine, Department of Blood TransfusionZhejiang Provincial People′s HospitalHangzhouP. R. China

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