Antiproliferative Prenylated Xanthones from the Pericarps of Garcinia mangostana
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Xanthones are a kind of natural products bearing a unique tricyclic aromatic system (C6–C3–C6) . The structural diversities of these compounds arise mainly from the different substitutions of the A and B rings in the skeleton, with isoprene, methoxyl, and hydroxyl groups, being the most frequently occurring substituents. Accordingly, xanthones can be classied into several groups including simple oxygenated xanthones, prenylated xanthones, xanthone glycosides, and xanthonolignoids based on these substituents . In recent years, xanthones have been identified as promising bioactive compounds with wide ranging and potentially usefull biological activities such as anticancer, anti-HIV, anti-inflammatory, antibacterial, and neurotrophic activities . Garcinia mangostana is a tropical fruit native to Southeast Asia that has long been noted for its medicinal and health promoting properties . Compared to the other species in the genus Garcinia, G. mangostanahas captured the most...
KeywordsColumn Chromatography CH3OH EtOAc Isoprene Xanthone
This work was financially supported by the Traditional Chinese Medicine Outstanding Young Talent Foundation of Zhejiang Province (2014ZQ005) and the Traditional Chinese Medicine Scientific Research Foundation of Zhejiang Province (2014ZB007).
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