Chemistry of Natural Compounds

, Volume 53, Issue 2, pp 345–350 | Cite as

Brown Alga Metabolites – Inhibitors of Marine Organism Fucoidan Hydrolases

  • A. S. Silchenko
  • T. I. Imbs
  • T. N. Zvyagintseva
  • S. A. Fedoreyev
  • S. P. Ermakova

Fucoidan hydrolase inhibitors were discovered for the first time. Metabolites in the aqueous EtOH extract of Fucus evanescens inhibited specifically the activity of enzymes involved in catabolism of brown-alga polysaccharides, i.e., fucoidanases (recombinant FFA from the marine bacterium Formosa algae KMM 3553T and PPF from the marine mollusk Patinopecten yessoensis) and glycosidases (recombinant α-L-fucosidase FucFa from F. algae and β-D-glucosidase G-II from the marine mollusk Littorina sitkana). The purified fucophlorethol fraction isolated from this extract inhibited recombinant fucoidanase FFA in the concentration range 10–50 μg/mL.


inhibitors enzymes fucoidan hydrolases brown alga phlorotannins 



The work was supported by RFBR Grant No. 15-04-01004.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • A. S. Silchenko
    • 1
  • T. I. Imbs
    • 1
  • T. N. Zvyagintseva
    • 1
  • S. A. Fedoreyev
    • 1
  • S. P. Ermakova
    • 1
  1. 1.G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East BranchRussian Academy of SciencesVladivostokRussia

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