Chemistry of Natural Compounds

, Volume 53, Issue 2, pp 304–309 | Cite as

Mass Spectrometric Analysis of Supramolecular Complexes of Glycyrrhizic Acid and Simvastatin

  • E. V. Vetrova
  • A. V. Lekar’
  • N. I. Borisenko
Article
  • 63 Downloads

Molecular complexes of glycyrrhizic acid (GA) and simvastatin (SV) were synthesized and studied for the first time using electrospray-ionization mass spectrometry (ESI-MS). Model complexes were synthesized in pure MeOH and its 25% aqueous solution. Complexation of GA and SV in the liquid phase was studied using ESI-MS and was confirmed using standard UV spectroscopy. Peaks for supramolecular GA–SV (1:1) complexes and a broad set of GA complexes with SV self-associates (GA–nSV, where n = 2, 3,…,5) were detected in mass spectra and indicated that competing processes were involved in synthesizing the GA–SV molecular complexes. The observed intensity changes of peaks for GA complexes with SV self-associates on going from MeOH to aqueous MeOH resulted from hydrophobic interactions that determined the effectiveness of SV self-association.

Keywords

simvaglyzin simvastatin glycyrrhizic acid supramolecular complexes electrospray-ionization mass spectrometry 

Notes

Acknowledgment

The work was supported financially by the Ministry of Education and Science of the RF under a state task, Project No. 1895.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • E. V. Vetrova
    • 1
  • A. V. Lekar’
    • 1
  • N. I. Borisenko
    • 1
  1. 1.Research Institute of Physical and Organic ChemistrySouthern Federal UniversityRostov-on-DonRussia

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